null

SMILES: COc1ccc(CC(=O)Nc2ccsc2-c2cnccn2)cc1

InChI Key: InChIKey=RVEHZFOKUTZKBA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50332084   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50332084 (2-(4-methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-...) Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cnccn2)cc1 Show InChI InChI=1S/C17H15N3O2S/c1-22-13-4-2-12(3-5-13)10-16(21)20-14-6-9-23-17(14)15-11-18-7-8-19-15/h2-9,11H,10H2,1H3,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay				Bioorg Med Chem Lett 20: 7303-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.066 BindingDB Entry DOI: 10.7270/Q20865JW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50332084 (2-(4-methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-...) Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cnccn2)cc1 Show InChI InChI=1S/C17H15N3O2S/c1-22-13-4-2-12(3-5-13)10-16(21)20-14-6-9-23-17(14)15-11-18-7-8-19-15/h2-9,11H,10H2,1H3,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay				Bioorg Med Chem Lett 20: 7303-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.066 BindingDB Entry DOI: 10.7270/Q20865JW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM50332084 (2-(4-methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-...) Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cnccn2)cc1 Show InChI InChI=1S/C17H15N3O2S/c1-22-13-4-2-12(3-5-13)10-16(21)20-14-6-9-23-17(14)15-11-18-7-8-19-15/h2-9,11H,10H2,1H3,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay				Bioorg Med Chem Lett 20: 7303-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.066 BindingDB Entry DOI: 10.7270/Q20865JW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50332084 (2-(4-methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-...) Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cnccn2)cc1 Show InChI InChI=1S/C17H15N3O2S/c1-22-13-4-2-12(3-5-13)10-16(21)20-14-6-9-23-17(14)15-11-18-7-8-19-15/h2-9,11H,10H2,1H3,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	US Patent	n/a	n/a	5.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
IMAGO PHARMACEUTICALS, INC. US Patent					Assay Description (1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...				US Patent US9796706 (2017) BindingDB Entry DOI: 10.7270/Q24T6MHK
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50332084 (2-(4-methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-...) Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cnccn2)cc1 Show InChI InChI=1S/C17H15N3O2S/c1-22-13-4-2-12(3-5-13)10-16(21)20-14-6-9-23-17(14)15-11-18-7-8-19-15/h2-9,11H,10H2,1H3,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay				Bioorg Med Chem Lett 20: 7303-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.066 BindingDB Entry DOI: 10.7270/Q20865JW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM50332084 (2-(4-methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-...) Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cnccn2)cc1 Show InChI InChI=1S/C17H15N3O2S/c1-22-13-4-2-12(3-5-13)10-16(21)20-14-6-9-23-17(14)15-11-18-7-8-19-15/h2-9,11H,10H2,1H3,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	US Patent	n/a	n/a	5.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
IMAGO PHARMACEUTICALS, INC. US Patent					Assay Description (1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...				US Patent US9796706 (2017) BindingDB Entry DOI: 10.7270/Q24T6MHK
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50332084 (2-(4-methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-...) Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cnccn2)cc1 Show InChI InChI=1S/C17H15N3O2S/c1-22-13-4-2-12(3-5-13)10-16(21)20-14-6-9-23-17(14)15-11-18-7-8-19-15/h2-9,11H,10H2,1H3,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	US Patent	n/a	n/a	5.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
IMAGO PHARMACEUTICALS, INC. US Patent					Assay Description (1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...				US Patent US9796706 (2017) BindingDB Entry DOI: 10.7270/Q24T6MHK
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM50332084 (2-(4-methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-...) Show SMILES COc1ccc(CC(=O)Nc2ccsc2-c2cnccn2)cc1 Show InChI InChI=1S/C17H15N3O2S/c1-22-13-4-2-12(3-5-13)10-16(21)20-14-6-9-23-17(14)15-11-18-7-8-19-15/h2-9,11H,10H2,1H3,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Elan Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of recombinant Erk2 after 60 mins by TR-FRET assay				Bioorg Med Chem Lett 20: 7303-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.066 BindingDB Entry DOI: 10.7270/Q20865JW
					More data for this Ligand-Target Pair