BDBM50332634 CHEMBL1630807::N-(4-Methoxyphenyl)-7-oxo-7,7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxamide

SMILES: COc1ccc(NC(=O)C23CC2C(N=O)c2ccccc2O3)cc1

InChI Key: InChIKey=PPETWINIGCTIHV-UHFFFAOYSA-N

Data: 1 KI  1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50332634   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332634 (CHEMBL1630807 | N-(4-Methoxyphenyl)-7-oxo-7,7a-dih...) Show SMILES COc1ccc(NC(=O)C23CC2C(N=O)c2ccccc2O3)cc1 Show InChI InChI=1S/C18H16N2O4/c1-23-12-8-6-11(7-9-12)19-17(21)18-10-14(18)16(20-22)13-4-2-3-5-15(13)24-18/h2-9,14,16H,10H2,1H3,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Domain Therapeutics SA Curated by ChEMBL					Assay Description Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assay				J Med Chem 53: 8775-9 (2010) Article DOI: 10.1021/jm101069m BindingDB Entry DOI: 10.7270/Q2WD40VJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50332634 (CHEMBL1630807 | N-(4-Methoxyphenyl)-7-oxo-7,7a-dih...) Show SMILES COc1ccc(NC(=O)C23CC2C(N=O)c2ccccc2O3)cc1 Show InChI InChI=1S/C18H16N2O4/c1-23-12-8-6-11(7-9-12)19-17(21)18-10-14(18)16(20-22)13-4-2-3-5-15(13)24-18/h2-9,14,16H,10H2,1H3,(H,19,21)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a
Domain Therapeutics SA Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assay				J Med Chem 53: 8775-9 (2010) Article DOI: 10.1021/jm101069m BindingDB Entry DOI: 10.7270/Q2WD40VJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332634 (CHEMBL1630807 | N-(4-Methoxyphenyl)-7-oxo-7,7a-dih...) Show SMILES COc1ccc(NC(=O)C23CC2C(N=O)c2ccccc2O3)cc1 Show InChI InChI=1S/C18H16N2O4/c1-23-12-8-6-11(7-9-12)19-17(21)18-10-14(18)16(20-22)13-4-2-3-5-15(13)24-18/h2-9,14,16H,10H2,1H3,(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Domain Therapeutics SA Curated by ChEMBL					Assay Description Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assay				J Med Chem 53: 8775-9 (2010) Article DOI: 10.1021/jm101069m BindingDB Entry DOI: 10.7270/Q2WD40VJ
					More data for this Ligand-Target Pair