null

SMILES: Nc1nc2ccc(cc2s1)-c1ccncc1

InChI Key: InChIKey=JDPMTRLFCSHYGB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50333221   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Homo sapiens (Human))	BDBM50333221 (6-(pyridin-4-yl)benzo[d]thiazol-2-amine | CHEMBL16...) Show SMILES Nc1nc2ccc(cc2s1)-c1ccncc1 Show InChI InChI=1S/C12H9N3S/c13-12-15-10-2-1-9(7-11(10)16-12)8-3-5-14-6-4-8/h1-7H,(H2,13,15)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay				Bioorg Med Chem Lett 25: 3189-93 (2015) BindingDB Entry DOI: 10.7270/Q2KK9DKR
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (Homo sapiens (Human))	BDBM50333221 (6-(pyridin-4-yl)benzo[d]thiazol-2-amine | CHEMBL16...) Show SMILES Nc1nc2ccc(cc2s1)-c1ccncc1 Show InChI InChI=1S/C12H9N3S/c13-12-15-10-2-1-9(7-11(10)16-12)8-3-5-14-6-4-8/h1-7H,(H2,13,15)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...				Bioorg Med Chem Lett 25: 3189-93 (2015) BindingDB Entry DOI: 10.7270/Q2KK9DKR
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-kinase alpha (Homo sapiens (Human))	BDBM50333221 (6-(pyridin-4-yl)benzo[d]thiazol-2-amine | CHEMBL16...) Show SMILES Nc1nc2ccc(cc2s1)-c1ccncc1 Show InChI InChI=1S/C12H9N3S/c13-12-15-10-2-1-9(7-11(10)16-12)8-3-5-14-6-4-8/h1-7H,(H2,13,15)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of N-terminal FLAG-tagged human full length recombinant PI4K3alpha using D-myo-phosphatidylinositol substrate and ATP incubated for 45 min...				Bioorg Med Chem Lett 25: 3189-93 (2015) BindingDB Entry DOI: 10.7270/Q2KK9DKR
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50333221 (6-(pyridin-4-yl)benzo[d]thiazol-2-amine | CHEMBL16...) Show SMILES Nc1nc2ccc(cc2s1)-c1ccncc1 Show InChI InChI=1S/C12H9N3S/c13-12-15-10-2-1-9(7-11(10)16-12)8-3-5-14-6-4-8/h1-7H,(H2,13,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D M£lndal Curated by ChEMBL					Assay Description Inhibition of human PI3K p110delta catalytic subunit by AlphaScreen assay				Bioorg Med Chem Lett 21: 829-35 (2011) Article DOI: 10.1016/j.bmcl.2010.11.087 BindingDB Entry DOI: 10.7270/Q298878P
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50333221 (6-(pyridin-4-yl)benzo[d]thiazol-2-amine | CHEMBL16...) Show SMILES Nc1nc2ccc(cc2s1)-c1ccncc1 Show InChI InChI=1S/C12H9N3S/c13-12-15-10-2-1-9(7-11(10)16-12)8-3-5-14-6-4-8/h1-7H,(H2,13,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D M£lndal Curated by ChEMBL					Assay Description Inhibition of human p110alpha PI3K fragment by AlphaScreen assay				Bioorg Med Chem Lett 21: 829-35 (2011) Article DOI: 10.1016/j.bmcl.2010.11.087 BindingDB Entry DOI: 10.7270/Q298878P
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM50333221 (6-(pyridin-4-yl)benzo[d]thiazol-2-amine | CHEMBL16...) Show SMILES Nc1nc2ccc(cc2s1)-c1ccncc1 Show InChI InChI=1S/C12H9N3S/c13-12-15-10-2-1-9(7-11(10)16-12)8-3-5-14-6-4-8/h1-7H,(H2,13,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D M£lndal Curated by ChEMBL					Assay Description Inhibition of human PI3K p110beta catalytic subunit by AlphaScreen competition assay				Bioorg Med Chem Lett 21: 829-35 (2011) Article DOI: 10.1016/j.bmcl.2010.11.087 BindingDB Entry DOI: 10.7270/Q298878P
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM50333221 (6-(pyridin-4-yl)benzo[d]thiazol-2-amine | CHEMBL16...) Show SMILES Nc1nc2ccc(cc2s1)-c1ccncc1 Show InChI InChI=1S/C12H9N3S/c13-12-15-10-2-1-9(7-11(10)16-12)8-3-5-14-6-4-8/h1-7H,(H2,13,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D M£lndal Curated by ChEMBL					Assay Description Inhibition of human PI3K p110gamma catalytic subunit by AlphaScreen assay				Bioorg Med Chem Lett 21: 829-35 (2011) Article DOI: 10.1016/j.bmcl.2010.11.087 BindingDB Entry DOI: 10.7270/Q298878P
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50333221 (6-(pyridin-4-yl)benzo[d]thiazol-2-amine | CHEMBL16...) Show SMILES Nc1nc2ccc(cc2s1)-c1ccncc1 Show InChI InChI=1S/C12H9N3S/c13-12-15-10-2-1-9(7-11(10)16-12)8-3-5-14-6-4-8/h1-7H,(H2,13,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha (unknown origin) pre-incubated for 20 mins before phosphatidylinositol 4, 5-bisphosphate substrate addition by kinase-glo plu...				Bioorg Med Chem Lett 25: 3189-93 (2015) BindingDB Entry DOI: 10.7270/Q2KK9DKR
					More data for this Ligand-Target Pair