BDBM50333500 (R)-2-(8-(1-(4-fluorophenyl)-N-methylcyclopropanecarboxamido)-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetic acid::CHEMBL1641814

SMILES: CN([C@@H]1CCc2c(CC(O)=O)c3cccnc3n2C1)C(=O)C1(CC1)c1ccc(F)cc1

InChI Key: InChIKey=WEVBYBXURYFREE-QGZVFWFLSA-N

Data: 3 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50333500   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
G protein-coupled receptor 44 (Homo sapiens (Human))	BDBM50333500 ((R)-2-(8-(1-(4-fluorophenyl)-N-methylcyclopropanec...) Show SMILES CN([C@@H]1CCc2c(CC(O)=O)c3cccnc3n2C1)C(=O)C1(CC1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C24H24FN3O3/c1-27(23(31)24(10-11-24)15-4-6-16(25)7-5-15)17-8-9-20-19(13-21(29)30)18-3-2-12-26-22(18)28(20)14-17/h2-7,12,17H,8-11,13-14H2,1H3,(H,29,30)/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Displacement of radioligand from human CRTH2 expressed in HEK293 cells by competitive binding assay				Bioorg Med Chem Lett 21: 841-5 (2011) Article DOI: 10.1016/j.bmcl.2010.11.084 BindingDB Entry DOI: 10.7270/Q24J0FCP
					More data for this Ligand-Target Pair
Prostanoid DP receptor (Homo sapiens (Human))	BDBM50333500 ((R)-2-(8-(1-(4-fluorophenyl)-N-methylcyclopropanec...) Show SMILES CN([C@@H]1CCc2c(CC(O)=O)c3cccnc3n2C1)C(=O)C1(CC1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C24H24FN3O3/c1-27(23(31)24(10-11-24)15-4-6-16(25)7-5-15)17-8-9-20-19(13-21(29)30)18-3-2-12-26-22(18)28(20)14-17/h2-7,12,17H,8-11,13-14H2,1H3,(H,29,30)/t17-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Displacement of radioligand from prostanoid DP receptor expressed in HEK293 cells by competitive binding assay				Bioorg Med Chem Lett 21: 841-5 (2011) Article DOI: 10.1016/j.bmcl.2010.11.084 BindingDB Entry DOI: 10.7270/Q24J0FCP
					More data for this Ligand-Target Pair
Prostanoid TP receptor (Homo sapiens (Human))	BDBM50333500 ((R)-2-(8-(1-(4-fluorophenyl)-N-methylcyclopropanec...) Show SMILES CN([C@@H]1CCc2c(CC(O)=O)c3cccnc3n2C1)C(=O)C1(CC1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C24H24FN3O3/c1-27(23(31)24(10-11-24)15-4-6-16(25)7-5-15)17-8-9-20-19(13-21(29)30)18-3-2-12-26-22(18)28(20)14-17/h2-7,12,17H,8-11,13-14H2,1H3,(H,29,30)/t17-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Displacement of radioligand from prostanoid TP receptor expressed in HEK293 cells by competitive binding assay				Bioorg Med Chem Lett 21: 841-5 (2011) Article DOI: 10.1016/j.bmcl.2010.11.084 BindingDB Entry DOI: 10.7270/Q24J0FCP
					More data for this Ligand-Target Pair
G protein-coupled receptor 44 (Homo sapiens (Human))	BDBM50333500 ((R)-2-(8-(1-(4-fluorophenyl)-N-methylcyclopropanec...) Show SMILES CN([C@@H]1CCc2c(CC(O)=O)c3cccnc3n2C1)C(=O)C1(CC1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C24H24FN3O3/c1-27(23(31)24(10-11-24)15-4-6-16(25)7-5-15)17-8-9-20-19(13-21(29)30)18-3-2-12-26-22(18)28(20)14-17/h2-7,12,17H,8-11,13-14H2,1H3,(H,29,30)/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at CRTH2 in human eosinophil assessed as effect of cellular shape change by EOS assay				Bioorg Med Chem Lett 21: 841-5 (2011) Article DOI: 10.1016/j.bmcl.2010.11.084 BindingDB Entry DOI: 10.7270/Q24J0FCP
					More data for this Ligand-Target Pair
G protein-coupled receptor 44 (Homo sapiens (Human))	BDBM50333500 ((R)-2-(8-(1-(4-fluorophenyl)-N-methylcyclopropanec...) Show SMILES CN([C@@H]1CCc2c(CC(O)=O)c3cccnc3n2C1)C(=O)C1(CC1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C24H24FN3O3/c1-27(23(31)24(10-11-24)15-4-6-16(25)7-5-15)17-8-9-20-19(13-21(29)30)18-3-2-12-26-22(18)28(20)14-17/h2-7,12,17H,8-11,13-14H2,1H3,(H,29,30)/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at human CRTH2 expressed in HEK293 cells assessed as inhibition of forskolin-induced increase intracellular [125I]cAMP level by s...				Bioorg Med Chem Lett 21: 841-5 (2011) Article DOI: 10.1016/j.bmcl.2010.11.084 BindingDB Entry DOI: 10.7270/Q24J0FCP
					More data for this Ligand-Target Pair