BDBM50334656 8-Chloro-2-methyl-5-((1-methyl-4-phenyl-1H-imidazol-2-ylthio)methyl)pyrazolo[1,5-c]quinazoline::CHEMBL1642572

SMILES: Cc1cc2c3ccc(Cl)cc3nc(CSc3nc(cn3C)-c3ccccc3)n2n1

InChI Key: InChIKey=DKPYPIGFNKHMIZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50334656   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50334656 (8-Chloro-2-methyl-5-((1-methyl-4-phenyl-1H-imidazo...) Show SMILES Cc1cc2c3ccc(Cl)cc3nc(CSc3nc(cn3C)-c3ccccc3)n2n1 Show InChI InChI=1S/C22H18ClN5S/c1-14-10-20-17-9-8-16(23)11-18(17)24-21(28(20)26-14)13-29-22-25-19(12-27(22)2)15-6-4-3-5-7-15/h3-12H,13H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Sassari Curated by ChEMBL					Assay Description Inhibition of human PDE10A expressed in Sf9 cells using [3H]cAMP by scintillation proximity assay				Bioorg Med Chem 19: 642-9 (2011) Article DOI: 10.1016/j.bmc.2010.10.038 BindingDB Entry DOI: 10.7270/Q2TT4R73
					More data for this Ligand-Target Pair