BDBM50334705 3-Benzenesulfonyl-thiazolidine-2-carboxylic acid(5-carbamoyl-adamantan-2-yl)-amide::CHEMBL1642619

SMILES: NC(=O)C12CC3CC(C1)C(NC(=O)C1SCCN1S(=O)(=O)c1ccccc1)C(C3)C2

InChI Key: InChIKey=AIHUEZKHRMINIK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50334705   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50334705 (3-Benzenesulfonyl-thiazolidine-2-carboxylic acid(5...) Show SMILES NC(=O)C12CC3CC(C1)C(NC(=O)C1SCCN1S(=O)(=O)c1ccccc1)C(C3)C2 |TLB:10:9:29.8.3:6.5.28,10:9:28:29.3.4,8:3:9.7.6:28,THB:8:7:28:29.3.4,4:3:9:6.5.28,4:5:9:29.8.3,1:3:9:6.5.28,1:3:9.7.6:28,(22.28,-41.5,;21.46,-40.2,;22.17,-38.83,;19.92,-40.26,;19.93,-38.73,;18.53,-38.15,;17.49,-39.39,;17.5,-40.97,;18.9,-41.53,;16,-41.39,;14.66,-40.62,;13.33,-41.39,;11.99,-40.63,;13.33,-42.93,;14.58,-43.84,;14.1,-45.31,;12.56,-45.31,;12.09,-43.84,;10.74,-43.09,;9.96,-41.75,;11.5,-41.75,;9.42,-43.88,;8.08,-43.13,;6.76,-43.92,;6.78,-45.46,;8.14,-46.21,;9.45,-45.41,;17.19,-40.11,;17.18,-38.63,;18.52,-40.6,)| Show InChI InChI=1S/C21H27N3O4S2/c22-20(26)21-10-13-8-14(11-21)17(15(9-13)12-21)23-18(25)19-24(6-7-29-19)30(27,28)16-4-2-1-3-5-16/h1-5,13-15,17,19H,6-12H2,(H2,22,26)(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Korea University Curated by ChEMBL					Assay Description Inhibition of mouse 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assay				Bioorg Med Chem Lett 21: 435-9 (2010) Article DOI: 10.1016/j.bmcl.2010.10.123 BindingDB Entry DOI: 10.7270/Q2FJ2H1K
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50334705 (3-Benzenesulfonyl-thiazolidine-2-carboxylic acid(5...) Show SMILES NC(=O)C12CC3CC(C1)C(NC(=O)C1SCCN1S(=O)(=O)c1ccccc1)C(C3)C2 |TLB:10:9:29.8.3:6.5.28,10:9:28:29.3.4,8:3:9.7.6:28,THB:8:7:28:29.3.4,4:3:9:6.5.28,4:5:9:29.8.3,1:3:9:6.5.28,1:3:9.7.6:28,(22.28,-41.5,;21.46,-40.2,;22.17,-38.83,;19.92,-40.26,;19.93,-38.73,;18.53,-38.15,;17.49,-39.39,;17.5,-40.97,;18.9,-41.53,;16,-41.39,;14.66,-40.62,;13.33,-41.39,;11.99,-40.63,;13.33,-42.93,;14.58,-43.84,;14.1,-45.31,;12.56,-45.31,;12.09,-43.84,;10.74,-43.09,;9.96,-41.75,;11.5,-41.75,;9.42,-43.88,;8.08,-43.13,;6.76,-43.92,;6.78,-45.46,;8.14,-46.21,;9.45,-45.41,;17.19,-40.11,;17.18,-38.63,;18.52,-40.6,)| Show InChI InChI=1S/C21H27N3O4S2/c22-20(26)21-10-13-8-14(11-21)17(15(9-13)12-21)23-18(25)19-24(6-7-29-19)30(27,28)16-4-2-1-3-5-16/h1-5,13-15,17,19H,6-12H2,(H2,22,26)(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
Korea University Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assay				Bioorg Med Chem Lett 21: 435-9 (2010) Article DOI: 10.1016/j.bmcl.2010.10.123 BindingDB Entry DOI: 10.7270/Q2FJ2H1K
					More data for this Ligand-Target Pair