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BDBM50334998 3-Biphenyl-4-yl-5-methyl-4-phenyl-4H-1,2,4-triazole::CHEMBL1649949

SMILES: Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1

InChI Key: InChIKey=LPJNRJXWXMNHIA-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50334998   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vasopressin V1a receptor


(Homo sapiens (Human))
BDBM50334998
PNG
(3-Biphenyl-4-yl-5-methyl-4-phenyl-4H-1,2,4-triazol...)
Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1
Show InChI InChI=1S/C21H17N3/c1-16-22-23-21(24(16)20-10-6-3-7-11-20)19-14-12-18(13-15-19)17-8-4-2-5-9-17/h2-15H,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds...


Bioorg Med Chem Lett 21: 5684-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.038
BindingDB Entry DOI: 10.7270/Q2TB179T
More data for this
Ligand-Target Pair
Glycine-1-transporter


(Homo sapiens (Human))
BDBM50334998
PNG
(3-Biphenyl-4-yl-5-methyl-4-phenyl-4H-1,2,4-triazol...)
Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1
Show InChI InChI=1S/C21H17N3/c1-16-22-23-21(24(16)20-10-6-3-7-11-20)19-14-12-18(13-15-19)17-8-4-2-5-9-17/h2-15H,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 880n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]glycine uptake at GlyT1 in rat C6 cells


J Med Chem 54: 387-91 (2011)


Article DOI: 10.1021/jm101031u
BindingDB Entry DOI: 10.7270/Q2H9965H
More data for this
Ligand-Target Pair
Glycine transporter 2


(Rattus norvegicus)
BDBM50334998
PNG
(3-Biphenyl-4-yl-5-methyl-4-phenyl-4H-1,2,4-triazol...)
Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1
Show InChI InChI=1S/C21H17N3/c1-16-22-23-21(24(16)20-10-6-3-7-11-20)19-14-12-18(13-15-19)17-8-4-2-5-9-17/h2-15H,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]glycine uptake at GlyT2 in rat C6 cells


J Med Chem 54: 387-91 (2011)


Article DOI: 10.1021/jm101031u
BindingDB Entry DOI: 10.7270/Q2H9965H
More data for this
Ligand-Target Pair