BDBM50335190 CHEMBL1650547::N-[3-[(3-Fluoro-1-azetidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Trifluoroacetate

SMILES: Cc1cn2c(cnc2c(Nc2cc(CN3CC(F)C3)ns2)n1)-c1cn[nH]c1

InChI Key: InChIKey=JZMGYGRZHAFRMN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50335190   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase B (Homo sapiens (Human))	BDBM50335190 (CHEMBL1650547 | N-[3-[(3-Fluoro-1-azetidinyl)methy...) Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CC(F)C3)ns2)n1)-c1cn[nH]c1 Show InChI InChI=1S/C17H17FN8S/c1-10-6-26-14(11-3-20-21-4-11)5-19-17(26)16(22-10)23-15-2-13(24-27-15)9-25-7-12(18)8-25/h2-6,12H,7-9H2,1H3,(H,20,21)(H,22,23)	PDB Reactome pathway KEGG B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	191	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Aurora B in human HCT116 cells assessed as inhibition of histone H3 phosphorylation by immunofluorescence assay				J Med Chem 54: 201-10 (2011) Article DOI: 10.1021/jm1010995 BindingDB Entry DOI: 10.7270/Q2VM4D76
					More data for this Ligand-Target Pair