BDBM50335460 1-((6-(5-cyclohexylbenzofuran-2-yl)pyridin-3-yl)methyl)azetidine-3-carboxylic acid::CHEMBL1651715

SMILES: OC(=O)C1CN(Cc2ccc(nc2)-c2cc3cc(ccc3o2)C2CCCCC2)C1

InChI Key: InChIKey=UUONBZVZZSPSJA-UHFFFAOYSA-N

Data: 3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50335460   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sphingosine 1-phosphate receptor 1 (Homo sapiens (Human))	BDBM50335460 (1-((6-(5-cyclohexylbenzofuran-2-yl)pyridin-3-yl)me...) Show SMILES OC(=O)C1CN(Cc2ccc(nc2)-c2cc3cc(ccc3o2)C2CCCCC2)C1 Show InChI InChI=1S/C24H26N2O3/c27-24(28)20-14-26(15-20)13-16-6-8-21(25-12-16)23-11-19-10-18(7-9-22(19)29-23)17-4-2-1-3-5-17/h6-12,17,20H,1-5,13-15H2,(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	720	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human S1P1R expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding				ACS Med Chem Lett 2: 97-101 (2011) Article DOI: 10.1021/ml100227q BindingDB Entry DOI: 10.7270/Q2WM1DP6
					More data for this Ligand-Target Pair
Sphingosine 1-phosphate receptor 3 (Homo sapiens (Human))	BDBM50335460 (1-((6-(5-cyclohexylbenzofuran-2-yl)pyridin-3-yl)me...) Show SMILES OC(=O)C1CN(Cc2ccc(nc2)-c2cc3cc(ccc3o2)C2CCCCC2)C1 Show InChI InChI=1S/C24H26N2O3/c27-24(28)20-14-26(15-20)13-16-6-8-21(25-12-16)23-11-19-10-18(7-9-22(19)29-23)17-4-2-1-3-5-17/h6-12,17,20H,1-5,13-15H2,(H,27,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human S1P3R expressed in CHO cells by Ca(2+) mobilization assay				ACS Med Chem Lett 2: 97-101 (2011) Article DOI: 10.1021/ml100227q BindingDB Entry DOI: 10.7270/Q2WM1DP6
					More data for this Ligand-Target Pair
Sphingosine 1-phosphate receptor 1 (Homo sapiens (Human))	BDBM50335460 (1-((6-(5-cyclohexylbenzofuran-2-yl)pyridin-3-yl)me...) Show SMILES OC(=O)C1CN(Cc2ccc(nc2)-c2cc3cc(ccc3o2)C2CCCCC2)C1 Show InChI InChI=1S/C24H26N2O3/c27-24(28)20-14-26(15-20)13-16-6-8-21(25-12-16)23-11-19-10-18(7-9-22(19)29-23)17-4-2-1-3-5-17/h6-12,17,20H,1-5,13-15H2,(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	424	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Induction of human GFP-tagged chimeric S1P1R internalization in human U2Os cells by fluorescence microscopy				ACS Med Chem Lett 2: 97-101 (2011) Article DOI: 10.1021/ml100227q BindingDB Entry DOI: 10.7270/Q2WM1DP6
					More data for this Ligand-Target Pair