BDBM50336267 CHEMBL1669737::ethyl 2-(3-nitrobenzylidene)-3-oxobutanoate
SMILES: CCOC(=O)C(=Cc1cccc(c1)[N+]([O-])=O)C(C)=O
InChI Key: InChIKey=YOPMSDPIOQUWFE-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glyoxalase 1 (GLO1) (Homo sapiens (Human)) | BDBM50336267 (CHEMBL1669737 | ethyl 2-(3-nitrobenzylidene)-3-oxo...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair |