null
SMILES: CN(C)c1ccc(NC(=O)c2cccc3c(N)nc(C)nc23)cn1
InChI Key: InChIKey=INPIJXDBDSYVCA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50336415 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50336415
(4-amino-N-(6-(dimethylamino)pyridin-3-yl)-2-methyl...)Show InChI InChI=1S/C17H18N6O/c1-10-20-15-12(16(18)21-10)5-4-6-13(15)17(24)22-11-7-8-14(19-9-11)23(2)3/h4-9H,1-3H3,(H,22,24)(H2,18,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha by fluorescene polarization assay |
Bioorg Med Chem Lett 21: 1270-4 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.026 BindingDB Entry DOI: 10.7270/Q2H1329M |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50336415
(4-amino-N-(6-(dimethylamino)pyridin-3-yl)-2-methyl...)Show InChI InChI=1S/C17H18N6O/c1-10-20-15-12(16(18)21-10)5-4-6-13(15)17(24)22-11-7-8-14(19-9-11)23(2)3/h4-9H,1-3H3,(H,22,24)(H2,18,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of mTOR |
Bioorg Med Chem Lett 21: 1270-4 (2011)
Article DOI: 10.1016/j.bmcl.2010.12.026 BindingDB Entry DOI: 10.7270/Q2H1329M |
More data for this Ligand-Target Pair | |