BindingDB logo
myBDB logout

null

SMILES: CN(C)c1ccc(NC(=O)c2c(C)ccc3c(N)nc(C)nc23)cn1

InChI Key: InChIKey=FFDGNFRWJOCMLQ-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50336416   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM50336416
PNG
(4-amino-N-(6-(dimethylamino)pyridin-3-yl)-2,7-dime...)
Show SMILES CN(C)c1ccc(NC(=O)c2c(C)ccc3c(N)nc(C)nc23)cn1
Show InChI InChI=1S/C18H20N6O/c1-10-5-7-13-16(21-11(2)22-17(13)19)15(10)18(25)23-12-6-8-14(20-9-12)24(3)4/h5-9H,1-4H3,(H,23,25)(H2,19,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 100n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3Kalpha by fluorescene polarization assay

Bioorg Med Chem Lett 21: 1270-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.026
BindingDB Entry DOI: 10.7270/Q2H1329M
More data for this
Ligand-Target Pair