null
SMILES: Cc1ccc(cc1NC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(c3cc(cc(c23)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)c1)C(=O)Nc1ccc(c2cc(cc(c12)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O
InChI Key: InChIKey=FIAFUQMPZJWCLV-UHFFFAOYSA-N
PDB links: 14 PDB IDs match this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universityof Illinois at Chicago Curated by ChEMBL | Assay Description Inhibition of purified HIV-2 reverse transcriptase | J Med Chem 35: 4846-53 (1992) BindingDB Entry DOI: 10.7270/Q2M0461N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.38E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois Curated by ChEMBL | Assay Description Inhibition of HIV1 RT | J Nat Prod 54: 143-54 Article DOI: 10.1021/np50073a012 BindingDB Entry DOI: 10.7270/Q2NK3HTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Reverse transcriptase (Human immunodeficiency virus 1) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.38E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
MediChem Research, Inc. Curated by ChEMBL | Assay Description Inhibition of HIV1 recombinant reverse transcriptase p66/p51 expressed in Escherichia coli | J Nat Prod 60: 884-8 (1997) Article DOI: 10.1021/np9700275 BindingDB Entry DOI: 10.7270/Q2JD50MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Compound was evaluated for the inhibition of microsomal 2,3-oxidosqualene cyclase in Candida albicans microsomes | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pyruvate kinase PKM (Homo sapiens (Human)) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Escherichia coli | J Med Chem 44: 4288-91 (2001) Article DOI: 10.1021/jm010948j | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pyruvate kinase PKM (Homo sapiens (Human)) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Escherichia coli | J Med Chem 44: 4288-91 (2001) Article DOI: 10.1021/jm010948j | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pyruvate kinase PKLR (Homo sapiens (Human)) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Escherichia coli | J Med Chem 44: 4288-91 (2001) Article DOI: 10.1021/jm010948j | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 2.62E+3 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Ikerchem, S.L.; Universidad del Pais Vasco US Patent | Assay Description 50 uM of substrate peptide (acetylated AMC-labeled peptide from p53 residues 379-382, RHKKAc, BioMol. Cat. #KI-177), 91 nM of human SIRT1 (full lengt... | US Patent US8835659 (2014) BindingDB Entry DOI: 10.7270/Q29K48ZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacylase sirtuin-5, mitochondrial (Homo sapiens (Human)) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Guiyang Medical University Curated by ChEMBL | Assay Description Inhibition of human SIRT5 assessed as reduction in desuccinylase activity using KQTAR(SuK)STGGKA substrate | Bioorg Med Chem Lett 25: 1671-4 (2015) Article DOI: 10.1016/j.bmcl.2015.03.018 BindingDB Entry DOI: 10.7270/Q2MK6FKB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
NAD-dependent protein deacylase sirtuin-5, mitochondrial (Homo sapiens (Human)) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Guiyang Medical University Curated by ChEMBL | Assay Description Inhibition of SIRT5 (unknown origin) using (DABCYL)ISGASE(SuK)DIVHSE(EDANS)G peptide substrate incubated for 1 hrs followed by 1 hr incubation with t... | Bioorg Med Chem Lett 25: 1671-4 (2015) Article DOI: 10.1016/j.bmcl.2015.03.018 BindingDB Entry DOI: 10.7270/Q2MK6FKB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |
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