BindingDB PrimarySearch

BDBM50337315 5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-amine::CHEMBL1682346::US9163007, 62

SMILES: Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1

InChI Key: InChIKey=VBNPWXWJZJNXEY-UHFFFAOYSA-N

Data: 9 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50337315
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cell division cycle 7-related protein kinase (Homo sapiens (Human))	BDBM50337315 (5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...) Show SMILES Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	12	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
AbbVie Inc. US Patent					Assay Description 11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...				US Patent US9163007 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DTG
AbbVie Inc. US Patent					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50337315 (5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...) Show SMILES Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	64	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate				Bioorg Med Chem Lett 21: 1476-9 (2011) Article DOI: 10.1016/j.bmcl.2011.01.007 BindingDB Entry DOI: 10.7270/Q2R78FGJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50337315 (5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...) Show SMILES Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	91	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of JAK2 after 1 hr using biotinylated PDKtide as substrate				Bioorg Med Chem Lett 21: 1476-9 (2011) Article DOI: 10.1016/j.bmcl.2011.01.007 BindingDB Entry DOI: 10.7270/Q2R78FGJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50337315 (5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...) Show SMILES Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	252	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Aurora kinase 2 after 1 hr using biotinylated kemptide as substrate				Bioorg Med Chem Lett 21: 1476-9 (2011) Article DOI: 10.1016/j.bmcl.2011.01.007 BindingDB Entry DOI: 10.7270/Q2R78FGJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50337315 (5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...) Show SMILES Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	265	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of GSK3-beta after 1 hr				Bioorg Med Chem Lett 21: 1476-9 (2011) Article DOI: 10.1016/j.bmcl.2011.01.007 BindingDB Entry DOI: 10.7270/Q2R78FGJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50337315 (5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...) Show SMILES Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of EGFR after 1 hr				Bioorg Med Chem Lett 21: 1476-9 (2011) Article DOI: 10.1016/j.bmcl.2011.01.007 BindingDB Entry DOI: 10.7270/Q2R78FGJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM50337315 (5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...) Show SMILES Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>3.75E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Pak4 after 1 hr using biotinylated L15 peptide as substrate				Bioorg Med Chem Lett 21: 1476-9 (2011) Article DOI: 10.1016/j.bmcl.2011.01.007 BindingDB Entry DOI: 10.7270/Q2R78FGJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50337315 (5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...) Show SMILES Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.98E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR after 1 hr				Bioorg Med Chem Lett 21: 1476-9 (2011) Article DOI: 10.1016/j.bmcl.2011.01.007 BindingDB Entry DOI: 10.7270/Q2R78FGJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50337315 (5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-am...) Show SMILES Nc1n[nH]c2ccc(cc12)-c1cn(Cc2ccccc2)nn1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>8.57E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Pim1 after 1 hr using biotinylated AL1peptide as substrate				Bioorg Med Chem Lett 21: 1476-9 (2011) Article DOI: 10.1016/j.bmcl.2011.01.007 BindingDB Entry DOI: 10.7270/Q2R78FGJ
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair