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SMILES: Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)Cc2ccc(C)cc2)[nH]n1

InChI Key: InChIKey=LTGPUQZRLFLMGW-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50337336   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50337336
PNG
(1-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2...)
Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)Cc2ccc(C)cc2)[nH]n1
Show InChI InChI=1S/C23H26N8O/c1-16-5-7-18(8-6-16)15-21(32)29-10-12-30(13-11-29)23-25-22(19-4-3-9-31(19)28-23)24-20-14-17(2)26-27-20/h3-9,14H,10-13,15H2,1-2H3,(H2,24,25,26,27,28)
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Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of JAK2 after 60 mins

Bioorg Med Chem Lett 21: 1425-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.022
BindingDB Entry DOI: 10.7270/Q2MG7PRT
More data for this
Ligand-Target Pair