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SMILES: Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)c2ccccc2)[nH]n1

InChI Key: InChIKey=BADQVFCFXXWJOF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50337341   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50337341
PNG
((4-(4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f...)
Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)c2ccccc2)[nH]n1
Show InChI InChI=1S/C21H22N8O/c1-15-14-18(25-24-15)22-19-17-8-5-9-29(17)26-21(23-19)28-12-10-27(11-13-28)20(30)16-6-3-2-4-7-16/h2-9,14H,10-13H2,1H3,(H2,22,23,24,25,26)
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Article
PubMed
n/an/a 2.20n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of JAK2 after 60 mins

Bioorg Med Chem Lett 21: 1425-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.022
BindingDB Entry DOI: 10.7270/Q2MG7PRT
More data for this
Ligand-Target Pair