BDBM50337916 (+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,3-dimethylbutan-1-amine::CHEMBL1684046::US10562878, Compound 45
SMILES: CNC(CC(C)C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
InChI Key: InChIKey=POKCWLLPLOIIOW-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50337916 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,3-dim...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 960 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation counting | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50337916 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,3-dim...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporter (Homo sapiens (Human)) | BDBM50337916 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,3-dim...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50337916 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,3-dim...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuroepithelial cell-transforming gene 1 protein (Homo sapiens) | BDBM50337916 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,3-dim...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 964 | n/a | n/a | n/a | n/a | n/a | n/a |
SUNOVION PHARAMCEUTICALS INC. US Patent | Assay Description Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293... | US Patent US10562878 (2020) BindingDB Entry DOI: 10.7270/Q2XP77BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50337916 ((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,3-dim...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunovion Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation counting | Bioorg Med Chem Lett 21: 1434-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.019 BindingDB Entry DOI: 10.7270/Q2CV4J2P | |||||||||||
More data for this Ligand-Target Pair |