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BDBM50338074 CHEMBL1684676::N-benzyl-2-(1H-indazol-3-yl)-N-methyl-1H-indole-6-carboxamide

SMILES: CN(Cc1ccccc1)C(=O)c1ccc2cc([nH]c2c1)-c1n[nH]c2ccccc12

InChI Key: InChIKey=FDJYILQLKXUKGQ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50338074   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50338074
PNG
(CHEMBL1684676 | N-benzyl-2-(1H-indazol-3-yl)-N-met...)
Show SMILES CN(Cc1ccccc1)C(=O)c1ccc2cc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C24H20N4O/c1-28(15-16-7-3-2-4-8-16)24(29)18-12-11-17-13-22(25-21(17)14-18)23-19-9-5-6-10-20(19)26-27-23/h2-14,25H,15H2,1H3,(H,26,27)
PDB
MMDB

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PC cid
PC sid
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Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Nycomed GmbH

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay


Bioorg Med Chem Lett 21: 1852-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.035
BindingDB Entry DOI: 10.7270/Q2MC90BW
More data for this
Ligand-Target Pair