BDBM50338315 (+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline-5-carbaldehyde O-phenyl oxime::CHEMBL1682426
SMILES: C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(\C=N\OCc3ccccc3)c12)-c1cccc2cc[nH]c12
InChI Key: InChIKey=YENJQTUDPVMEAA-CJJDCIQDSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50338315 ((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals Curated by ChEMBL | Assay Description Displacement of radiolabeled dexamethasone from GR | Bioorg Med Chem Lett 21: 1697-700 (2011) Article DOI: 10.1016/j.bmcl.2011.01.093 BindingDB Entry DOI: 10.7270/Q2639Q12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50338315 ((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ... | Bioorg Med Chem Lett 21: 1697-700 (2011) Article DOI: 10.1016/j.bmcl.2011.01.093 BindingDB Entry DOI: 10.7270/Q2639Q12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50338315 ((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone | Bioorg Med Chem Lett 21: 1697-700 (2011) Article DOI: 10.1016/j.bmcl.2011.01.093 BindingDB Entry DOI: 10.7270/Q2639Q12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM50338315 ((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals Curated by ChEMBL | Assay Description Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr... | Bioorg Med Chem Lett 21: 1697-700 (2011) Article DOI: 10.1016/j.bmcl.2011.01.093 BindingDB Entry DOI: 10.7270/Q2639Q12 | |||||||||||
More data for this Ligand-Target Pair |