BDBM50338447 CHEMBL1682981::trans-3-(N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylsulfamoyl)benzamide

SMILES: CN([C@H]1CC[C@@H](CC1)[C@H](N)Cc1cc(F)ccc1F)S(=O)(=O)c1cccc(c1)C(N)=O

InChI Key: InChIKey=FWKVIWIXXGHRSD-CFCCAZDESA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50338447   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast activation protein alpha (Homo sapiens (Human))	BDBM50338447 (CHEMBL1682981 | trans-3-(N-(4-((R)-1-amino-2-(2,5-...) Show SMILES CN([C@H]1CC[C@@H](CC1)[C@H](N)Cc1cc(F)ccc1F)S(=O)(=O)c1cccc(c1)C(N)=O |r,wU:8.9,2.1,wD:5.4,(-.09,-22.06,;-.09,-20.52,;-1.42,-19.75,;-2.76,-20.52,;-4.09,-19.75,;-4.08,-18.21,;-2.76,-17.43,;-1.42,-18.21,;-5.41,-17.44,;-5.42,-15.9,;-6.75,-18.22,;-8.08,-17.45,;-8.09,-15.9,;-9.42,-15.13,;-9.43,-13.59,;-10.75,-15.91,;-10.75,-17.45,;-9.42,-18.22,;-9.42,-19.76,;1.25,-19.76,;.47,-18.42,;2.01,-18.42,;2.57,-20.53,;2.57,-22.06,;3.89,-22.83,;5.23,-22.06,;5.22,-20.52,;3.89,-19.76,;6.55,-19.75,;7.89,-20.52,;6.55,-18.21,)| Show InChI InChI=1S/C22H27F2N3O3S/c1-27(31(29,30)19-4-2-3-15(12-19)22(26)28)18-8-5-14(6-9-18)21(25)13-16-11-17(23)7-10-20(16)24/h2-4,7,10-12,14,18,21H,5-6,8-9,13,25H2,1H3,(H2,26,28)/t14-,18-,21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of FAP				Bioorg Med Chem Lett 21: 1880-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.060 BindingDB Entry DOI: 10.7270/Q2SX6DJG
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human))	BDBM50338447 (CHEMBL1682981 | trans-3-(N-(4-((R)-1-amino-2-(2,5-...) Show SMILES CN([C@H]1CC[C@@H](CC1)[C@H](N)Cc1cc(F)ccc1F)S(=O)(=O)c1cccc(c1)C(N)=O |r,wU:8.9,2.1,wD:5.4,(-.09,-22.06,;-.09,-20.52,;-1.42,-19.75,;-2.76,-20.52,;-4.09,-19.75,;-4.08,-18.21,;-2.76,-17.43,;-1.42,-18.21,;-5.41,-17.44,;-5.42,-15.9,;-6.75,-18.22,;-8.08,-17.45,;-8.09,-15.9,;-9.42,-15.13,;-9.43,-13.59,;-10.75,-15.91,;-10.75,-17.45,;-9.42,-18.22,;-9.42,-19.76,;1.25,-19.76,;.47,-18.42,;2.01,-18.42,;2.57,-20.53,;2.57,-22.06,;3.89,-22.83,;5.23,-22.06,;5.22,-20.52,;3.89,-19.76,;6.55,-19.75,;7.89,-20.52,;6.55,-18.21,)| Show InChI InChI=1S/C22H27F2N3O3S/c1-27(31(29,30)19-4-2-3-15(12-19)22(26)28)18-8-5-14(6-9-18)21(25)13-16-11-17(23)7-10-20(16)24/h2-4,7,10-12,14,18,21H,5-6,8-9,13,25H2,1H3,(H2,26,28)/t14-,18-,21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of QPP				Bioorg Med Chem Lett 21: 1880-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.060 BindingDB Entry DOI: 10.7270/Q2SX6DJG
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 9 (Homo sapiens (Human))	BDBM50338447 (CHEMBL1682981 | trans-3-(N-(4-((R)-1-amino-2-(2,5-...) Show SMILES CN([C@H]1CC[C@@H](CC1)[C@H](N)Cc1cc(F)ccc1F)S(=O)(=O)c1cccc(c1)C(N)=O |r,wU:8.9,2.1,wD:5.4,(-.09,-22.06,;-.09,-20.52,;-1.42,-19.75,;-2.76,-20.52,;-4.09,-19.75,;-4.08,-18.21,;-2.76,-17.43,;-1.42,-18.21,;-5.41,-17.44,;-5.42,-15.9,;-6.75,-18.22,;-8.08,-17.45,;-8.09,-15.9,;-9.42,-15.13,;-9.43,-13.59,;-10.75,-15.91,;-10.75,-17.45,;-9.42,-18.22,;-9.42,-19.76,;1.25,-19.76,;.47,-18.42,;2.01,-18.42,;2.57,-20.53,;2.57,-22.06,;3.89,-22.83,;5.23,-22.06,;5.22,-20.52,;3.89,-19.76,;6.55,-19.75,;7.89,-20.52,;6.55,-18.21,)| Show InChI InChI=1S/C22H27F2N3O3S/c1-27(31(29,30)19-4-2-3-15(12-19)22(26)28)18-8-5-14(6-9-18)21(25)13-16-11-17(23)7-10-20(16)24/h2-4,7,10-12,14,18,21H,5-6,8-9,13,25H2,1H3,(H2,26,28)/t14-,18-,21-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of DPP9				Bioorg Med Chem Lett 21: 1880-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.060 BindingDB Entry DOI: 10.7270/Q2SX6DJG
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50338447 (CHEMBL1682981 | trans-3-(N-(4-((R)-1-amino-2-(2,5-...) Show SMILES CN([C@H]1CC[C@@H](CC1)[C@H](N)Cc1cc(F)ccc1F)S(=O)(=O)c1cccc(c1)C(N)=O |r,wU:8.9,2.1,wD:5.4,(-.09,-22.06,;-.09,-20.52,;-1.42,-19.75,;-2.76,-20.52,;-4.09,-19.75,;-4.08,-18.21,;-2.76,-17.43,;-1.42,-18.21,;-5.41,-17.44,;-5.42,-15.9,;-6.75,-18.22,;-8.08,-17.45,;-8.09,-15.9,;-9.42,-15.13,;-9.43,-13.59,;-10.75,-15.91,;-10.75,-17.45,;-9.42,-18.22,;-9.42,-19.76,;1.25,-19.76,;.47,-18.42,;2.01,-18.42,;2.57,-20.53,;2.57,-22.06,;3.89,-22.83,;5.23,-22.06,;5.22,-20.52,;3.89,-19.76,;6.55,-19.75,;7.89,-20.52,;6.55,-18.21,)| Show InChI InChI=1S/C22H27F2N3O3S/c1-27(31(29,30)19-4-2-3-15(12-19)22(26)28)18-8-5-14(6-9-18)21(25)13-16-11-17(23)7-10-20(16)24/h2-4,7,10-12,14,18,21H,5-6,8-9,13,25H2,1H3,(H2,26,28)/t14-,18-,21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	99	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of DPP4				Bioorg Med Chem Lett 21: 1880-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.060 BindingDB Entry DOI: 10.7270/Q2SX6DJG
					More data for this Ligand-Target Pair
Dipeptidyl peptidase VIII (Homo sapiens (Human))	BDBM50338447 (CHEMBL1682981 | trans-3-(N-(4-((R)-1-amino-2-(2,5-...) Show SMILES CN([C@H]1CC[C@@H](CC1)[C@H](N)Cc1cc(F)ccc1F)S(=O)(=O)c1cccc(c1)C(N)=O |r,wU:8.9,2.1,wD:5.4,(-.09,-22.06,;-.09,-20.52,;-1.42,-19.75,;-2.76,-20.52,;-4.09,-19.75,;-4.08,-18.21,;-2.76,-17.43,;-1.42,-18.21,;-5.41,-17.44,;-5.42,-15.9,;-6.75,-18.22,;-8.08,-17.45,;-8.09,-15.9,;-9.42,-15.13,;-9.43,-13.59,;-10.75,-15.91,;-10.75,-17.45,;-9.42,-18.22,;-9.42,-19.76,;1.25,-19.76,;.47,-18.42,;2.01,-18.42,;2.57,-20.53,;2.57,-22.06,;3.89,-22.83,;5.23,-22.06,;5.22,-20.52,;3.89,-19.76,;6.55,-19.75,;7.89,-20.52,;6.55,-18.21,)| Show InChI InChI=1S/C22H27F2N3O3S/c1-27(31(29,30)19-4-2-3-15(12-19)22(26)28)18-8-5-14(6-9-18)21(25)13-16-11-17(23)7-10-20(16)24/h2-4,7,10-12,14,18,21H,5-6,8-9,13,25H2,1H3,(H2,26,28)/t14-,18-,21-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of DPP8				Bioorg Med Chem Lett 21: 1880-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.060 BindingDB Entry DOI: 10.7270/Q2SX6DJG
					More data for this Ligand-Target Pair