BDBM50338470 CHEMBL1683104::trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylnicotinamide

SMILES: CN([C@H]1CC[C@@H](CC1)[C@H](N)Cc1cc(F)ccc1F)C(=O)c1cccnc1

InChI Key: InChIKey=OPHYBCBINOHLIH-LXGCGDOSSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50338470   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast activation protein alpha (Homo sapiens (Human))	BDBM50338470 (CHEMBL1683104 | trans-N-(4-((R)-1-amino-2-(2,5-dif...) Show SMILES CN([C@H]1CC[C@@H](CC1)[C@H](N)Cc1cc(F)ccc1F)C(=O)c1cccnc1 |r,wU:8.9,2.1,wD:5.5,(.25,-21.74,;.25,-20.2,;-1.08,-19.42,;-2.42,-20.19,;-3.74,-19.42,;-3.74,-17.89,;-2.41,-17.11,;-1.08,-17.88,;-5.07,-17.12,;-5.07,-15.58,;-6.4,-17.89,;-7.74,-17.12,;-7.75,-15.57,;-9.08,-14.81,;-9.09,-13.27,;-10.41,-15.58,;-10.41,-17.12,;-9.08,-17.89,;-9.08,-19.43,;1.59,-19.43,;1.59,-17.89,;2.92,-20.2,;4.24,-19.43,;5.57,-20.2,;5.58,-21.75,;4.24,-22.51,;2.91,-21.74,)| Show InChI InChI=1S/C21H25F2N3O/c1-26(21(27)15-3-2-10-25-13-15)18-7-4-14(5-8-18)20(24)12-16-11-17(22)6-9-19(16)23/h2-3,6,9-11,13-14,18,20H,4-5,7-8,12,24H2,1H3/t14-,18-,20-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of FAP				Bioorg Med Chem Lett 21: 1880-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.060 BindingDB Entry DOI: 10.7270/Q2SX6DJG
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 9 (Homo sapiens (Human))	BDBM50338470 (CHEMBL1683104 | trans-N-(4-((R)-1-amino-2-(2,5-dif...) Show SMILES CN([C@H]1CC[C@@H](CC1)[C@H](N)Cc1cc(F)ccc1F)C(=O)c1cccnc1 |r,wU:8.9,2.1,wD:5.5,(.25,-21.74,;.25,-20.2,;-1.08,-19.42,;-2.42,-20.19,;-3.74,-19.42,;-3.74,-17.89,;-2.41,-17.11,;-1.08,-17.88,;-5.07,-17.12,;-5.07,-15.58,;-6.4,-17.89,;-7.74,-17.12,;-7.75,-15.57,;-9.08,-14.81,;-9.09,-13.27,;-10.41,-15.58,;-10.41,-17.12,;-9.08,-17.89,;-9.08,-19.43,;1.59,-19.43,;1.59,-17.89,;2.92,-20.2,;4.24,-19.43,;5.57,-20.2,;5.58,-21.75,;4.24,-22.51,;2.91,-21.74,)| Show InChI InChI=1S/C21H25F2N3O/c1-26(21(27)15-3-2-10-25-13-15)18-7-4-14(5-8-18)20(24)12-16-11-17(22)6-9-19(16)23/h2-3,6,9-11,13-14,18,20H,4-5,7-8,12,24H2,1H3/t14-,18-,20-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of DPP9				Bioorg Med Chem Lett 21: 1880-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.060 BindingDB Entry DOI: 10.7270/Q2SX6DJG
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50338470 (CHEMBL1683104 | trans-N-(4-((R)-1-amino-2-(2,5-dif...) Show SMILES CN([C@H]1CC[C@@H](CC1)[C@H](N)Cc1cc(F)ccc1F)C(=O)c1cccnc1 |r,wU:8.9,2.1,wD:5.5,(.25,-21.74,;.25,-20.2,;-1.08,-19.42,;-2.42,-20.19,;-3.74,-19.42,;-3.74,-17.89,;-2.41,-17.11,;-1.08,-17.88,;-5.07,-17.12,;-5.07,-15.58,;-6.4,-17.89,;-7.74,-17.12,;-7.75,-15.57,;-9.08,-14.81,;-9.09,-13.27,;-10.41,-15.58,;-10.41,-17.12,;-9.08,-17.89,;-9.08,-19.43,;1.59,-19.43,;1.59,-17.89,;2.92,-20.2,;4.24,-19.43,;5.57,-20.2,;5.58,-21.75,;4.24,-22.51,;2.91,-21.74,)| Show InChI InChI=1S/C21H25F2N3O/c1-26(21(27)15-3-2-10-25-13-15)18-7-4-14(5-8-18)20(24)12-16-11-17(22)6-9-19(16)23/h2-3,6,9-11,13-14,18,20H,4-5,7-8,12,24H2,1H3/t14-,18-,20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of DPP4				Bioorg Med Chem Lett 21: 1880-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.060 BindingDB Entry DOI: 10.7270/Q2SX6DJG
					More data for this Ligand-Target Pair
Dipeptidyl peptidase VIII (Homo sapiens (Human))	BDBM50338470 (CHEMBL1683104 | trans-N-(4-((R)-1-amino-2-(2,5-dif...) Show SMILES CN([C@H]1CC[C@@H](CC1)[C@H](N)Cc1cc(F)ccc1F)C(=O)c1cccnc1 |r,wU:8.9,2.1,wD:5.5,(.25,-21.74,;.25,-20.2,;-1.08,-19.42,;-2.42,-20.19,;-3.74,-19.42,;-3.74,-17.89,;-2.41,-17.11,;-1.08,-17.88,;-5.07,-17.12,;-5.07,-15.58,;-6.4,-17.89,;-7.74,-17.12,;-7.75,-15.57,;-9.08,-14.81,;-9.09,-13.27,;-10.41,-15.58,;-10.41,-17.12,;-9.08,-17.89,;-9.08,-19.43,;1.59,-19.43,;1.59,-17.89,;2.92,-20.2,;4.24,-19.43,;5.57,-20.2,;5.58,-21.75,;4.24,-22.51,;2.91,-21.74,)| Show InChI InChI=1S/C21H25F2N3O/c1-26(21(27)15-3-2-10-25-13-15)18-7-4-14(5-8-18)20(24)12-16-11-17(22)6-9-19(16)23/h2-3,6,9-11,13-14,18,20H,4-5,7-8,12,24H2,1H3/t14-,18-,20-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of DPP8				Bioorg Med Chem Lett 21: 1880-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.060 BindingDB Entry DOI: 10.7270/Q2SX6DJG
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human))	BDBM50338470 (CHEMBL1683104 | trans-N-(4-((R)-1-amino-2-(2,5-dif...) Show SMILES CN([C@H]1CC[C@@H](CC1)[C@H](N)Cc1cc(F)ccc1F)C(=O)c1cccnc1 |r,wU:8.9,2.1,wD:5.5,(.25,-21.74,;.25,-20.2,;-1.08,-19.42,;-2.42,-20.19,;-3.74,-19.42,;-3.74,-17.89,;-2.41,-17.11,;-1.08,-17.88,;-5.07,-17.12,;-5.07,-15.58,;-6.4,-17.89,;-7.74,-17.12,;-7.75,-15.57,;-9.08,-14.81,;-9.09,-13.27,;-10.41,-15.58,;-10.41,-17.12,;-9.08,-17.89,;-9.08,-19.43,;1.59,-19.43,;1.59,-17.89,;2.92,-20.2,;4.24,-19.43,;5.57,-20.2,;5.58,-21.75,;4.24,-22.51,;2.91,-21.74,)| Show InChI InChI=1S/C21H25F2N3O/c1-26(21(27)15-3-2-10-25-13-15)18-7-4-14(5-8-18)20(24)12-16-11-17(22)6-9-19(16)23/h2-3,6,9-11,13-14,18,20H,4-5,7-8,12,24H2,1H3/t14-,18-,20-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of QPP				Bioorg Med Chem Lett 21: 1880-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.060 BindingDB Entry DOI: 10.7270/Q2SX6DJG
					More data for this Ligand-Target Pair