BindingDB PrimarySearch

BDBM50338873 CHEMBL1684800::N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-2-methylbenzamide

SMILES: COc1ccc(Cn2ncc(NC(=O)c3cc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)ccc3C)c2N)cc1

InChI Key: InChIKey=ZJDFSKSBQBPOSK-UHFFFAOYSA-N

Data: 20 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50338873
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
CDK2/Cyclin E/G1/S-specific cyclin E2 (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.13	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of CDK2/cyclin E				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description inhibition of JNK3				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.73	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description inhibition of GSK3-beta				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.87	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description inhibition of RAF1				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3 (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of CDK1/cyclin B				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.13	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of FAK				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.79	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of c-Src				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.42	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description inhibition of KDR				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18.2	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description inhibition of MEK1				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21.5	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description inhibition of FGFR3				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51.6	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description inhibition of IGF-1R				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	101	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of EGFR				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of C-Raf assessed as [33P]gamma-ATP incorporation into substrate after 40 mins by scintillation counting				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	167	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description inhibition of PLK1				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	194	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of c-MET				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	277	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description inhibition of RON				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description inhibition of JNK1a1 at 10 uM				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description inhibition of mTOR				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of ERK2				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50338873 (CHEMBL1684800 \| N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.71	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of ALK				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
Hanyang University Curated by ChEMBL					More data for this Ligand-Target Pair