BindingDB PrimarySearch

BDBM50339059 3-cyclobutyl-1-(2-phenylquinolin-7-yl)-imidazo[1,5-a]pyrazin-8-ylamine::3-cyclobutyl-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine::CHEMBL261805

SMILES: Nc1nccn2c(nc(-c3ccc4ccc(nc4c3)-c3ccccc3)c12)C1CCC1

InChI Key: InChIKey=LFQVOSHWRZTZHW-UHFFFAOYSA-N

Data: 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50339059
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50339059 (3-cyclobutyl-1-(2-phenylquinolin-7-yl)-imidazo[1,5...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometry				ACS Med Chem Lett 1: 510-515 (2010) Article DOI: 10.1021/ml100178g BindingDB Entry DOI: 10.7270/Q2J966NZ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50339059 (3-cyclobutyl-1-(2-phenylquinolin-7-yl)-imidazo[1,5...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human IGF1R in presence of 100 uM ATP				ACS Med Chem Lett 1: 510-515 (2010) Article DOI: 10.1021/ml100178g BindingDB Entry DOI: 10.7270/Q2J966NZ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50339059 (3-cyclobutyl-1-(2-phenylquinolin-7-yl)-imidazo[1,5...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
OSI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of CYP3A4				Bioorg Med Chem 16: 1359-75 (2008) Article DOI: 10.1016/j.bmc.2007.10.061 BindingDB Entry DOI: 10.7270/Q2WH2QVH
OSI Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50339059 (3-cyclobutyl-1-(2-phenylquinolin-7-yl)-imidazo[1,5...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
OSI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cells				Bioorg Med Chem 16: 1359-75 (2008) Article DOI: 10.1016/j.bmc.2007.10.061 BindingDB Entry DOI: 10.7270/Q2WH2QVH
OSI Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50339059 (3-cyclobutyl-1-(2-phenylquinolin-7-yl)-imidazo[1,5...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
OSI Pharmaceuticals, Inc Curated by ChEMBL					Assay Description Inhibition of IGF-1R by ELISA				Bioorg Med Chem Lett 21: 2092-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.139 BindingDB Entry DOI: 10.7270/Q23N23QH
OSI Pharmaceuticals, Inc Curated by ChEMBL					More data for this Ligand-Target Pair