BDBM50339062 4-(3-(4-amino-5-(8-fluoro-2-phenylquinolin-7-yl)imidazo[1,5-f][1,2,4]triazin-7-yl)cyclobutyl)piperazine-1-carbaldehyde::CHEMBL1688361
SMILES: Nc1ncnn2c(nc(-c3ccc4ccc(nc4c3F)-c3ccccc3)c12)[C@@H]1C[C@@H](C1)N1CCN(CC1)C=O
InChI Key: InChIKey=GVHNKGKLBRLAOO-OYRHEFFESA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Insulin-like growth factor I receptor (Homo sapiens (Human)) | BDBM50339062 (4-(3-(4-amino-5-(8-fluoro-2-phenylquinolin-7-yl)im...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometry | ACS Med Chem Lett 1: 510-515 (2010) Article DOI: 10.1021/ml100178g BindingDB Entry DOI: 10.7270/Q2J966NZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin receptor (Homo sapiens (Human)) | BDBM50339062 (4-(3-(4-amino-5-(8-fluoro-2-phenylquinolin-7-yl)im...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of auto-phosphorylation of human IR expressed in human HepG2 cells after 2 hrs by luminometry | ACS Med Chem Lett 1: 510-515 (2010) Article DOI: 10.1021/ml100178g BindingDB Entry DOI: 10.7270/Q2J966NZ | |||||||||||
More data for this Ligand-Target Pair |