BDBM50339190 CHEMBL443683::telomestatin
SMILES: Cc1oc2nc1c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1nc(co1)c1SCc(n1)c1[nH]c2c(C)o1
InChI Key: InChIKey=VYWLOEZWRJWFGS-UKDGSBPWSA-N
Data: 7 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50339190 (CHEMBL443683 | telomestatin) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita` degli Studi La Sapienza Curated by ChEMBL | Assay Description Inhibition of human Telomerase activity in cell free system by TRAP assay | J Med Chem 54: 1140-56 (2011) Article DOI: 10.1021/jm1013665 BindingDB Entry DOI: 10.7270/Q2GB24CR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50339190 (CHEMBL443683 | telomestatin) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 0.640 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut National de la Sant£ et de la Recherche M£dicale Curated by ChEMBL | Assay Description Inhibition of human telomerase expressed in HEK293T cells treated before telomerase elongation by telomeric repeat amplification protocol assay | Proc Natl Acad Sci USA 104: 17347-52 (2007) Article DOI: 10.1073/pnas.0707365104 BindingDB Entry DOI: 10.7270/Q26974FQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50339190 (CHEMBL443683 | telomestatin) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut National de la Sant£ et de la Recherche M£dicale Curated by ChEMBL | Assay Description Inhibition of human telomerase expressed in HEK293T cells treated after telomerase elongation by telomeric repeat amplification protocol assay | Proc Natl Acad Sci USA 104: 17347-52 (2007) Article DOI: 10.1073/pnas.0707365104 BindingDB Entry DOI: 10.7270/Q26974FQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50339190 (CHEMBL443683 | telomestatin) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article | n/a | n/a | 5.01E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of telomerase (unknown origin) | Citation and Details Article DOI: 10.1007/s00044-011-9594-4 BindingDB Entry DOI: 10.7270/Q2X63QV3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50339190 (CHEMBL443683 | telomestatin) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut National de la Sant£ et de la Recherche M£dicale Curated by ChEMBL | Assay Description Inhibition of human telomerase expressed in HEK293T cells in presence of primer TS by primer extension assay | Proc Natl Acad Sci USA 104: 17347-52 (2007) Article DOI: 10.1073/pnas.0707365104 BindingDB Entry DOI: 10.7270/Q26974FQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50339190 (CHEMBL443683 | telomestatin) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut National de la Sant£ et de la Recherche M£dicale Curated by ChEMBL | Assay Description Inhibition of human telomerase expressed in in HEK293T cells in presence of primer (T2AG3)4 by primer extension assay | Proc Natl Acad Sci USA 104: 17347-52 (2007) Article DOI: 10.1073/pnas.0707365104 BindingDB Entry DOI: 10.7270/Q26974FQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50339190 (CHEMBL443683 | telomestatin) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut National de la Sant£ et de la Recherche M£dicale Curated by ChEMBL | Assay Description Inhibition of human telomerase expressed in HEK293T cells in presence of primer (T2AG3)3 by primer extension assay | Proc Natl Acad Sci USA 104: 17347-52 (2007) Article DOI: 10.1073/pnas.0707365104 BindingDB Entry DOI: 10.7270/Q26974FQ | |||||||||||
More data for this Ligand-Target Pair |