BDBM50339252 (Z/E)-(S)-2-((5-chloro-2-oxoindolin-3-ylidene)methylamino)-N-isopentyl-4-methylpentanamide::CHEMBL1689604
SMILES: CC(C)CCNC(=O)[C@H](CC(C)C)N=CC1C(=O)Nc2ccc(Cl)cc12
InChI Key: InChIKey=IZXORWGCHMBXDT-DAFXYXGESA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cysteine protease falcipain-3 (Plasmodium falciparum) | BDBM50339252 ((Z/E)-(S)-2-((5-chloro-2-oxoindolin-3-ylidene)meth...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Lisbon Curated by ChEMBL | Assay Description Inhibition of Plasmodium falciparum falcipain 3 incubated with compound for 10 mins before addition of 25 uM Z-Leu-Arg-AMC substrate by fluorescence ... | Eur J Med Chem 46: 927-33 (2011) Article DOI: 10.1016/j.ejmech.2011.01.008 BindingDB Entry DOI: 10.7270/Q2ZC8345 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Falcipain-2 (Plasmodium falciparum) | BDBM50339252 ((Z/E)-(S)-2-((5-chloro-2-oxoindolin-3-ylidene)meth...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Lisbon Curated by ChEMBL | Assay Description Inhibition of Plasmodium falciparum falcipain 2 incubated with compound for 10 mins before addition of 25 uM Z-Leu-Arg-AMC substrate by fluorescence ... | Eur J Med Chem 46: 927-33 (2011) Article DOI: 10.1016/j.ejmech.2011.01.008 BindingDB Entry DOI: 10.7270/Q2ZC8345 | |||||||||||
More data for this Ligand-Target Pair |