BDBM50339263 (Z/E)-(S)-ethyl 2-((2-oxoindolin-3-ylidene)methylamino)-3-phenylpropanoate::CHEMBL1689602

SMILES: CCOC(=O)[C@H](Cc1ccccc1)N=CC1C(=O)Nc2ccccc12

InChI Key: InChIKey=YTYOQSTWAOCQPL-DAFXYXGESA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50339263   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Falcipain-2 (Plasmodium falciparum)	BDBM50339263 ((Z/E)-(S)-ethyl 2-((2-oxoindolin-3-ylidene)methyla...) Show SMILES CCOC(=O)[C@H](Cc1ccccc1)N=CC1C(=O)Nc2ccccc12 |r,w:14.15| Show InChI InChI=1S/C20H20N2O3/c1-2-25-20(24)18(12-14-8-4-3-5-9-14)21-13-16-15-10-6-7-11-17(15)22-19(16)23/h3-11,13,16,18H,2,12H2,1H3,(H,22,23)/t16?,18-/m0/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum falcipain 2 incubated with compound for 10 mins before addition of 25 uM Z-Leu-Arg-AMC substrate by fluorescence ...				Eur J Med Chem 46: 927-33 (2011) Article DOI: 10.1016/j.ejmech.2011.01.008 BindingDB Entry DOI: 10.7270/Q2ZC8345
					More data for this Ligand-Target Pair