BDBM50339269 (Z/E)-6-chloro-3-((3-(7-chloroquinolin-4-ylamino)propylamino)methylene)indolin-2-one::CHEMBL1689613

SMILES: Clc1ccc2C(C=NCCCNc3ccnc4cc(Cl)ccc34)C(=O)Nc2c1

InChI Key: InChIKey=VHFSKMTVNCLSNE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50339269   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Falcipain-2 (Plasmodium falciparum)	BDBM50339269 ((Z/E)-6-chloro-3-((3-(7-chloroquinolin-4-ylamino)p...) Show SMILES Clc1ccc2C(C=NCCCNc3ccnc4cc(Cl)ccc34)C(=O)Nc2c1 |w:6.5| Show InChI InChI=1S/C21H18Cl2N4O/c22-13-3-5-16-18(6-9-26-19(16)10-13)25-8-1-7-24-12-17-15-4-2-14(23)11-20(15)27-21(17)28/h2-6,9-12,17H,1,7-8H2,(H,25,26)(H,27,28)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum falcipain 2 incubated with compound for 10 mins before addition of 25 uM Z-Leu-Arg-AMC substrate by fluorescence ...				Eur J Med Chem 46: 927-33 (2011) Article DOI: 10.1016/j.ejmech.2011.01.008 BindingDB Entry DOI: 10.7270/Q2ZC8345
					More data for this Ligand-Target Pair