BDBM50339278 3-Phenyl-2,5-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one::CHEMBL1689645

SMILES: FC(F)(F)c1[nH]n2c(nc(cc2=O)C(F)(F)F)c1-c1ccccc1

InChI Key: InChIKey=JKVODKKDOQKVDQ-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50339278   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-gated potassium channel subunit Kv7.2/Kv7.3 (Homo sapiens (Human))	BDBM50339278 (3-Phenyl-2,5-bis(trifluoromethyl)pyrazolo[1,5-a]py...) Show SMILES FC(F)(F)c1[nH]n2c(nc(cc2=O)C(F)(F)F)c1-c1ccccc1 Show InChI InChI=1S/C14H7F6N3O/c15-13(16,17)8-6-9(24)23-12(21-8)10(7-4-2-1-3-5-7)11(22-23)14(18,19)20/h1-6,22H	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.46E+3	n/a	n/a	n/a	n/a
Hebei Medical University Curated by ChEMBL					Assay Description Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assay				Eur J Med Chem 46: 934-43 (2011) Article DOI: 10.1016/j.ejmech.2011.01.010 BindingDB Entry DOI: 10.7270/Q2TM7BDF
					More data for this Ligand-Target Pair