BDBM50339280 3-(Naphthalen-1-yl)-2,5-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one::CHEMBL1689653

SMILES: FC(F)(F)c1[nH]n2c(nc(cc2=O)C(F)(F)F)c1-c1cccc2ccccc12

InChI Key: InChIKey=XLVQKUBZQAUDRE-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50339280   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-gated potassium channel subunit Kv7.2/Kv7.3 (Homo sapiens (Human))	BDBM50339280 (3-(Naphthalen-1-yl)-2,5-bis(trifluoromethyl)pyrazo...) Show SMILES FC(F)(F)c1[nH]n2c(nc(cc2=O)C(F)(F)F)c1-c1cccc2ccccc12 |(12.13,-33.97,;11.37,-35.32,;9.82,-35.33,;10.58,-33.97,;12.15,-36.65,;11.53,-38.06,;12.68,-39.08,;14.01,-38.31,;15.34,-39.09,;15.34,-40.63,;14.01,-41.4,;12.67,-40.63,;11.33,-41.41,;16.68,-41.41,;16.68,-42.96,;18.02,-40.64,;18.02,-42.18,;13.68,-36.8,;14.51,-35.5,;13.79,-34.14,;14.62,-32.83,;16.17,-32.9,;16.88,-34.27,;18.41,-34.34,;19.13,-35.69,;18.3,-37,;16.76,-36.93,;16.05,-35.57,)| Show InChI InChI=1S/C18H9F6N3O/c19-17(20,21)12-8-13(28)27-16(25-12)14(15(26-27)18(22,23)24)11-7-3-5-9-4-1-2-6-10(9)11/h1-8,26H	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.98E+3	n/a	n/a	n/a	n/a
Hebei Medical University Curated by ChEMBL					Assay Description Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assay				Eur J Med Chem 46: 934-43 (2011) Article DOI: 10.1016/j.ejmech.2011.01.010 BindingDB Entry DOI: 10.7270/Q2TM7BDF
					More data for this Ligand-Target Pair