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BDBM50339328 CHEMBL1689814::N-{Dicyclohexyl[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

SMILES: CC1(C)CC(Nc2c(cnn12)C(=O)NC(C1CCCCC1)(C1CCCCC1)c1ccc(cc1)C(F)(F)F)c1ccccc1

InChI Key: InChIKey=TZHIMMVPSIKMOW-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50339328   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))		BDBM50339328
PNG
(CHEMBL1689814 | N-{Dicyclohexyl[4-(trifluoromethyl...)
Show SMILES CC1(C)CC(Nc2c(cnn12)C(=O)NC(C1CCCCC1)(C1CCCCC1)c1ccc(cc1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C35H43F3N4O/c1-33(2)22-30(24-12-6-3-7-13-24)40-31-29(23-39-42(31)33)32(43)41-34(25-14-8-4-9-15-25,26-16-10-5-11-17-26)27-18-20-28(21-19-27)35(36,37)38/h3,6-7,12-13,18-21,23,25-26,30,40H,4-5,8-11,14-17,22H2,1-2H3,(H,41,43)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay

J Med Chem 54: 1430-40 (2011)


Article DOI: 10.1021/jm101452x
BindingDB Entry DOI: 10.7270/Q2K35TZ9
More data for this
Ligand-Target Pair