BDBM50339342 (5S)-(+)-N-[1-Ethyl-1-(4-methylphenyl)propyl]-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide Hydrochloride::CHEMBL1688100

SMILES: CCC(CC)(NC(=O)c1cnn2c1N[C@@H](CC2(C)C)c1ccccc1)c1ccc(C)cc1

InChI Key: InChIKey=HUZMHENQDRSAGB-QHCPKHFHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50339342   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium-sensing receptor (CaSR) (Homo sapiens (Human))	BDBM50339342 ((5S)-(+)-N-[1-Ethyl-1-(4-methylphenyl)propyl]-7,7-...) Show SMILES CCC(CC)(NC(=O)c1cnn2c1N[C@@H](CC2(C)C)c1ccccc1)c1ccc(C)cc1 |r| Show InChI InChI=1S/C27H34N4O/c1-6-27(7-2,21-15-13-19(3)14-16-21)30-25(32)22-18-28-31-24(22)29-23(17-26(31,4)5)20-11-9-8-10-12-20/h8-16,18,23,29H,6-7,17H2,1-5H3,(H,30,32)/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay				J Med Chem 54: 1430-40 (2011) Article DOI: 10.1021/jm101452x BindingDB Entry DOI: 10.7270/Q2K35TZ9
					More data for this Ligand-Target Pair