BDBM50339351 (+/-)-cis-3-(4-Chlorophenyl)-3-(4-hydroxycyclopent-2-enyloxy)-2-(4-methylbenzyl)isoindolin-1-one::CHEMBL1688256::US8618158, NU8295

SMILES: Cc1ccc(CN2C(=O)c3ccccc3C2(O[C@@H]2C[C@H](O)C=C2)c2ccc(Cl)cc2)cc1

InChI Key: InChIKey=GQWCFDLMBXJXGH-ASPAYWPZSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50339351   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50339351 ((+/-)-cis-3-(4-Chlorophenyl)-3-(4-hydroxycyclopent...) Show SMILES Cc1ccc(CN2C(=O)c3ccccc3C2(O[C@@H]2C[C@H](O)C=C2)c2ccc(Cl)cc2)cc1 |r,c:23| Show InChI InChI=1S/C27H24ClNO3/c1-18-6-8-19(9-7-18)17-29-26(31)24-4-2-3-5-25(24)27(29,20-10-12-21(28)13-11-20)32-23-15-14-22(30)16-23/h2-15,22-23,30H,16-17H2,1H3/t22-,23+,27?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Newcastle University Curated by ChEMBL					Assay Description Inhibition of Mdm2 -p53 protein interaction by ELISA				J Med Chem 54: 1233-43 (2011) Article DOI: 10.1021/jm1011929 BindingDB Entry DOI: 10.7270/Q29K4BHN
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50339351 ((+/-)-cis-3-(4-Chlorophenyl)-3-(4-hydroxycyclopent...) Show SMILES Cc1ccc(CN2C(=O)c3ccccc3C2(O[C@@H]2C[C@H](O)C=C2)c2ccc(Cl)cc2)cc1 |r,c:23| Show InChI InChI=1S/C27H24ClNO3/c1-18-6-8-19(9-7-18)17-29-26(31)24-4-2-3-5-25(24)27(29,20-10-12-21(28)13-11-20)32-23-15-14-22(30)16-23/h2-15,22-23,30H,16-17H2,1H3/t22-,23+,27?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	25
Cancer Research Technology Limited US Patent					Assay Description Streptavidin-coated 96-well plates are used to immobilise a biotin-tagged IP3 p53-derived peptide (MPRFMDYWEGLN). This is a peptide analogue derived ...				US Patent US8618158 (2013) BindingDB Entry DOI: 10.7270/Q27D2STZ
					More data for this Ligand-Target Pair