BDBM50339362 (+/-)-3-(4-Chlorophenyl)-3-(4-hydroxymethylbenzyloxy)-2-(4-nitrobenzyl)-2,3-dihydroisoindol-1-one::CHEMBL1688267

SMILES: OCc1ccc(COC2(N(Cc3ccc(cc3)[N+]([O-])=O)C(=O)c3ccccc23)c2ccc(Cl)cc2)cc1

InChI Key: InChIKey=GLUMFQWGVLXSJP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50339362   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50339362 ((+/-)-3-(4-Chlorophenyl)-3-(4-hydroxymethylbenzylo...) Show SMILES OCc1ccc(COC2(N(Cc3ccc(cc3)[N+]([O-])=O)C(=O)c3ccccc23)c2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C29H23ClN2O5/c30-24-13-11-23(12-14-24)29(37-19-22-7-5-21(18-33)6-8-22)27-4-2-1-3-26(27)28(34)31(29)17-20-9-15-25(16-10-20)32(35)36/h1-16,33H,17-19H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	980	n/a	n/a	n/a	n/a	n/a	n/a
Newcastle University Curated by ChEMBL					Assay Description Inhibition of Mdm2 -p53 protein interaction by ELISA				J Med Chem 54: 1233-43 (2011) Article DOI: 10.1021/jm1011929 BindingDB Entry DOI: 10.7270/Q29K4BHN
					More data for this Ligand-Target Pair