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BDBM50339369 (+/-)-3-(4-chlorophenyl)-3-((1-(hydroxymethyl)cyclopropyl)methoxy)-2-(4-nitrobenzyl)isoindolin-1-one::CHEMBL1688274

SMILES: OCC1(COC2(N(Cc3ccc(cc3)[N+]([O-])=O)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1

InChI Key: InChIKey=FWMIQNMFNBHEKJ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50339369   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50339369
PNG
((+/-)-3-(4-chlorophenyl)-3-((1-(hydroxymethyl)cycl...)
Show SMILES OCC1(COC2(N(Cc3ccc(cc3)[N+]([O-])=O)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C26H23ClN2O5/c27-20-9-7-19(8-10-20)26(34-17-25(16-30)13-14-25)23-4-2-1-3-22(23)24(31)28(26)15-18-5-11-21(12-6-18)29(32)33/h1-12,30H,13-17H2
PDB
MMDB

NCI pathway
Reactome pathway
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PC cid
PC sid
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Patents

Article
PubMed
n/an/a 230n/an/an/an/an/an/a



Newcastle University

Curated by ChEMBL


Assay Description
Inhibition of Mdm2 -p53 protein interaction by ELISA


J Med Chem 54: 1233-43 (2011)


Article DOI: 10.1021/jm1011929
BindingDB Entry DOI: 10.7270/Q29K4BHN
More data for this
Ligand-Target Pair