BDBM50339375 (+/-)-2-(4-Bromobenzyl)-3-(4-chlorophenyl)-3-((1-(hydroxymethyl)cyclopropyl)methoxy)isoindolin-1-one::CHEMBL1688280::US8618158, NU8417

SMILES: OCC1(COC2(N(Cc3ccc(Br)cc3)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1

InChI Key: InChIKey=YMEMJYRVAROGJU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50339375   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50339375 ((+/-)-2-(4-Bromobenzyl)-3-(4-chlorophenyl)-3-((1-(...) Show SMILES OCC1(COC2(N(Cc3ccc(Br)cc3)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C26H23BrClNO3/c27-20-9-5-18(6-10-20)15-29-24(31)22-3-1-2-4-23(22)26(29,19-7-11-21(28)12-8-19)32-17-25(16-30)13-14-25/h1-12,30H,13-17H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Newcastle University Curated by ChEMBL					Assay Description Inhibition of Mdm2 -p53 protein interaction by ELISA				J Med Chem 54: 1233-43 (2011) Article DOI: 10.1021/jm1011929 BindingDB Entry DOI: 10.7270/Q29K4BHN
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50339375 ((+/-)-2-(4-Bromobenzyl)-3-(4-chlorophenyl)-3-((1-(...) Show SMILES OCC1(COC2(N(Cc3ccc(Br)cc3)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C26H23BrClNO3/c27-20-9-5-18(6-10-20)15-29-24(31)22-3-1-2-4-23(22)26(29,19-7-11-21(28)12-8-19)32-17-25(16-30)13-14-25/h1-12,30H,13-17H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	25
Cancer Research Technology Limited US Patent					Assay Description Streptavidin-coated 96-well plates are used to immobilise a biotin-tagged IP3 p53-derived peptide (MPRFMDYWEGLN). This is a peptide analogue derived ...				US Patent US8618158 (2013) BindingDB Entry DOI: 10.7270/Q27D2STZ
					More data for this Ligand-Target Pair