BDBM50339691 4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)benzamide::CHEMBL1688990
SMILES: COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(cc2)N(C)C)CC1
InChI Key: InChIKey=LBZHOUJGVUYWGV-UHFFFAOYSA-N
Data: 9 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50339691 (4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperaz...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Displacement of of [125I]-IABN from human D3 receptor expressed in HEK293 cell membranes after 60 mins by filtration binding assay | Bioorg Med Chem Lett 25: 519-23 (2015) Article DOI: 10.1016/j.bmcl.2014.12.023 BindingDB Entry DOI: 10.7270/Q27W6DS9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50339691 (4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperaz...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Displacement of [125I]-IABN from human D3 receptor transfected in human HEK 293 cells by gamma-counting | J Med Chem 54: 1555-64 (2011) Article DOI: 10.1021/jm101323b BindingDB Entry DOI: 10.7270/Q2WD40W0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50339691 (4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperaz...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Displacement of of [3H]8-OH-DPAT from human 5HT1A receptor after 60 mins by filtration binding assay | Bioorg Med Chem Lett 25: 519-23 (2015) Article DOI: 10.1016/j.bmcl.2014.12.023 BindingDB Entry DOI: 10.7270/Q27W6DS9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50339691 (4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperaz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Displacement of of [125I]-IABN from human D2 long receptor expressed in HEK293 cell membranes after 60 mins by filtration binding assay | Bioorg Med Chem Lett 25: 519-23 (2015) Article DOI: 10.1016/j.bmcl.2014.12.023 BindingDB Entry DOI: 10.7270/Q27W6DS9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50339691 (4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperaz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 34.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Displacement of [125I]-IABN from human D2 receptor transfected in human HEK 293 cells by gamma-counting | J Med Chem 54: 1555-64 (2011) Article DOI: 10.1021/jm101323b BindingDB Entry DOI: 10.7270/Q2WD40W0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50339691 (4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperaz...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 896 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Displacement of of [125I]-IABN from human D4 receptor expressed in HEK293 cell membranes after 60 mins by filtration binding assay | Bioorg Med Chem Lett 25: 519-23 (2015) Article DOI: 10.1016/j.bmcl.2014.12.023 BindingDB Entry DOI: 10.7270/Q27W6DS9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50339691 (4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperaz...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 896 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Binding affinity to human D4 receptor transfected in human HEK293 cells by gamma-counting | J Med Chem 54: 1555-64 (2011) Article DOI: 10.1021/jm101323b BindingDB Entry DOI: 10.7270/Q2WD40W0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Cavia porcellus (Guinea pig)) | BDBM50339691 (4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperaz...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Displacement of [3H]-pentazocine from guinea pig sigma1 receptor by liquid scintillation counting | J Med Chem 54: 1555-64 (2011) Article DOI: 10.1021/jm101323b BindingDB Entry DOI: 10.7270/Q2WD40W0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma-2 (RAT) | BDBM50339691 (4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperaz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Displacement of [3H]-DTG from rat sigma2 receptor by liquid scintillation counting | J Med Chem 54: 1555-64 (2011) Article DOI: 10.1021/jm101323b BindingDB Entry DOI: 10.7270/Q2WD40W0 | |||||||||||
More data for this Ligand-Target Pair |