BDBM50339724 4-[1-Ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]-pyrimidin-3-yl]carbonyl}amino)-propyl]benzoic acid::CHEMBL1689061

SMILES: CCC(CC)(NC(=O)c1c(C)nn2c1N[C@H](CC2(C)C)c1ccccc1)c1ccc(cc1)C(O)=O

InChI Key: InChIKey=ZZLCKVFUCQCUST-JOCHJYFZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50339724   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium-sensing receptor (CaSR) (Homo sapiens (Human))	BDBM50339724 (4-[1-Ethyl-1-({[(5R)-2,7,7-trimethyl-5-phenyl-4,5,...) Show SMILES CCC(CC)(NC(=O)c1c(C)nn2c1N[C@H](CC2(C)C)c1ccccc1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C28H34N4O3/c1-6-28(7-2,21-15-13-20(14-16-21)26(34)35)30-25(33)23-18(3)31-32-24(23)29-22(17-27(32,4)5)19-11-9-8-10-12-19/h8-16,22,29H,6-7,17H2,1-5H3,(H,30,33)(H,34,35)/t22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Antagonist activity at CaSR expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding after 10 mins by scintillation counting				Bioorg Med Chem 19: 1881-94 (2011) Article DOI: 10.1016/j.bmc.2011.02.001 BindingDB Entry DOI: 10.7270/Q2MW2HFZ
					More data for this Ligand-Target Pair