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BDBM50339737 CHEMBL1689042::rac-N-[1-Ethyl-1-(4-methylphenyl)propyl]-7,7-dimethyl-5-phenyl-2-propyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide hydrochloride

SMILES: CCCc1nn2c(NC(CC2(C)C)c2ccccc2)c1C(=O)NC(CC)(CC)c1ccc(C)cc1

InChI Key: InChIKey=ILFRNNHGJGXAAK-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50339737   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))		BDBM50339737
PNG
(CHEMBL1689042 | rac-N-[1-Ethyl-1-(4-methylphenyl)p...)
Show SMILES CCCc1nn2c(NC(CC2(C)C)c2ccccc2)c1C(=O)NC(CC)(CC)c1ccc(C)cc1
Show InChI InChI=1S/C30H40N4O/c1-7-13-24-26(28(35)32-30(8-2,9-3)23-18-16-21(4)17-19-23)27-31-25(22-14-11-10-12-15-22)20-29(5,6)34(27)33-24/h10-12,14-19,25,31H,7-9,13,20H2,1-6H3,(H,32,35)
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Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at CaSR expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding after 10 mins by scintillation counting

Bioorg Med Chem 19: 1881-94 (2011)


Article DOI: 10.1016/j.bmc.2011.02.001
BindingDB Entry DOI: 10.7270/Q2MW2HFZ
More data for this
Ligand-Target Pair