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BDBM50339739 CHEMBL1689041::rac-2-Ethyl-N-[1-ethyl-1-(4-methylphenyl)propyl]-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]-pyrimidine-3-carboxamide hydrochloride

SMILES: CCc1nn2c(NC(CC2(C)C)c2ccccc2)c1C(=O)NC(CC)(CC)c1ccc(C)cc1

InChI Key: InChIKey=YNGORAWSOMCJNK-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50339739   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))		BDBM50339739
PNG
(CHEMBL1689041 | rac-2-Ethyl-N-[1-ethyl-1-(4-methyl...)
Show SMILES CCc1nn2c(NC(CC2(C)C)c2ccccc2)c1C(=O)NC(CC)(CC)c1ccc(C)cc1
Show InChI InChI=1S/C29H38N4O/c1-7-23-25(27(34)31-29(8-2,9-3)22-17-15-20(4)16-18-22)26-30-24(21-13-11-10-12-14-21)19-28(5,6)33(26)32-23/h10-18,24,30H,7-9,19H2,1-6H3,(H,31,34)
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PC sid
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Similars
Article
PubMed
n/an/a 6.70n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at CaSR expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding after 10 mins by scintillation counting

Bioorg Med Chem 19: 1881-94 (2011)


Article DOI: 10.1016/j.bmc.2011.02.001
BindingDB Entry DOI: 10.7270/Q2MW2HFZ
More data for this
Ligand-Target Pair