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SMILES: CCC(CC)(NC(=O)c1c2NC(CC(C)(C)n2nc1-c1ccccc1)c1ccccc1)c1ccc(C)cc1

InChI Key: InChIKey=ABVXVJZOQZBIDC-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50339746   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50339746
PNG
(CHEMBL1689044 | rac-N-[1-Ethyl-1-(4-methylphenyl)p...)
Show SMILES CCC(CC)(NC(=O)c1c2NC(CC(C)(C)n2nc1-c1ccccc1)c1ccccc1)c1ccc(C)cc1
Show InChI InChI=1S/C33H38N4O/c1-6-33(7-2,26-20-18-23(3)19-21-26)35-31(38)28-29(25-16-12-9-13-17-25)36-37-30(28)34-27(22-32(37,4)5)24-14-10-8-11-15-24/h8-21,27,34H,6-7,22H2,1-5H3,(H,35,38)
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Article
PubMed
n/an/a 81n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at CaSR expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding after 10 mins by scintillation counting

Bioorg Med Chem 19: 1881-94 (2011)


Article DOI: 10.1016/j.bmc.2011.02.001
BindingDB Entry DOI: 10.7270/Q2MW2HFZ
More data for this
Ligand-Target Pair