BDBM50339806 (3beta,18beta,20beta)-N-[-3-(Acetoxy)-11-oxo-30-norolean-12-en-20-yl]urea::CHEMBL1689173
SMILES: CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)NC(N)=O)C1(C)C
InChI Key: InChIKey=WBHDMKZEFCLSRV-XWEVEMRCSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
11-beta-hydroxysteroid dehydrogenase 2 (Homo sapiens (Human)) | BDBM50339806 ((3beta,18beta,20beta)-N-[-3-(Acetoxy)-11-oxo-30-no...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Technology Curated by ChEMBL | Assay Description Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-[3H]cortisol to cortisone after 10 mins by scintillation... | Bioorg Med Chem 19: 1866-80 (2011) Article DOI: 10.1016/j.bmc.2011.02.005 BindingDB Entry DOI: 10.7270/Q2VD6ZR7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50339806 ((3beta,18beta,20beta)-N-[-3-(Acetoxy)-11-oxo-30-no...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Technology Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [1,2-[3H]cortisone to cortisol after 10 mins by scint... | Bioorg Med Chem 19: 1866-80 (2011) Article DOI: 10.1016/j.bmc.2011.02.005 BindingDB Entry DOI: 10.7270/Q2VD6ZR7 | |||||||||||
More data for this Ligand-Target Pair |