BDBM50339809 (5aR,7aR,7bS,9aS,12S,13aR,15aR,15bS)-2,3,4,5,5a,6,7,7a,7b,8,9,9a,10,11,12,13,13a,15,15a,15b-Eicosahydro-5,5,7a,7b,9a,12,15b-heptamethyl-3,15-dioxo-N-hydroxy-N-methyl-1Hchryseno[2,1-c]azepine-12-carboxylic acid amid::CHEMBL1689280

SMILES: CN(O)C(=O)[C@@]1(C)CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CCC(=O)NC(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1

InChI Key: InChIKey=AUQXBLHDEASREV-GJIZTULQSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50339809   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 2 (Homo sapiens (Human))	BDBM50339809 ((5aR,7aR,7bS,9aS,12S,13aR,15aR,15bS)-2,3,4,5,5a,6,...) Show SMILES CN(O)C(=O)[C@@]1(C)CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CCC(=O)NC(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1 |r,c:15| Show InChI InChI=1S/C31H48N2O4/c1-26(2)22-9-12-31(7)24(29(22,5)11-10-23(35)32-26)21(34)17-19-20-18-28(4,25(36)33(8)37)14-13-27(20,3)15-16-30(19,31)6/h17,20,22,24,37H,9-16,18H2,1-8H3,(H,32,35)/t20-,22-,24+,27+,28-,29-,30+,31+/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
University of Technology Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-[3H]cortisol to cortisone after 10 mins by scintillation...				Bioorg Med Chem 19: 1866-80 (2011) Article DOI: 10.1016/j.bmc.2011.02.005 BindingDB Entry DOI: 10.7270/Q2VD6ZR7
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50339809 ((5aR,7aR,7bS,9aS,12S,13aR,15aR,15bS)-2,3,4,5,5a,6,...) Show SMILES CN(O)C(=O)[C@@]1(C)CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CCC(=O)NC(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1 |r,c:15| Show InChI InChI=1S/C31H48N2O4/c1-26(2)22-9-12-31(7)24(29(22,5)11-10-23(35)32-26)21(34)17-19-20-18-28(4,25(36)33(8)37)14-13-27(20,3)15-16-30(19,31)6/h17,20,22,24,37H,9-16,18H2,1-8H3,(H,32,35)/t20-,22-,24+,27+,28-,29-,30+,31+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Technology Curated by ChEMBL					Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [1,2-[3H]cortisone to cortisol after 10 mins by scint...				Bioorg Med Chem 19: 1866-80 (2011) Article DOI: 10.1016/j.bmc.2011.02.005 BindingDB Entry DOI: 10.7270/Q2VD6ZR7
					More data for this Ligand-Target Pair