Found 9 hits for monomerid = 50340121 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Insulin receptor
(Homo sapiens (Human)) | BDBM50340121
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of INSR |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075 BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this Ligand-Target Pair | |
Insulin-like growth factor I receptor
(Homo sapiens (Human)) | BDBM50340121
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075 BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this Ligand-Target Pair | |
Insulin-like growth factor I receptor
(Homo sapiens (Human)) | BDBM50340121
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075 BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50340121
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Aurora A |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075 BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50340121
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 746 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Tie2 |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075 BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50340121
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of cMet |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075 BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50340121
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 853 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of EGFR |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075 BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50340121
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075 BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50340121
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 711 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of CDK2 |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075 BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this Ligand-Target Pair | |