BDBM50340122 CHEMBL1760036::N4-(naphthalen-2-yl)-N2-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine

SMILES: COc1cc(Nc2nccc(Nc3ccc4ccccc4c3)n2)cc(OC)c1OC

InChI Key: InChIKey=OQZLCEIUKFMPCK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50340122   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50340122 (CHEMBL1760036 | N4-(naphthalen-2-yl)-N2-(3,4,5-tri...) Show SMILES COc1cc(Nc2nccc(Nc3ccc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C23H22N4O3/c1-28-19-13-18(14-20(29-2)22(19)30-3)26-23-24-11-10-21(27-23)25-17-9-8-15-6-4-5-7-16(15)12-17/h4-14H,1-3H3,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr				Bioorg Med Chem Lett 21: 2394-9 (2011) Article DOI: 10.1016/j.bmcl.2011.02.075 BindingDB Entry DOI: 10.7270/Q28G8M0D
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50340122 (CHEMBL1760036 | N4-(naphthalen-2-yl)-N2-(3,4,5-tri...) Show SMILES COc1cc(Nc2nccc(Nc3ccc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C23H22N4O3/c1-28-19-13-18(14-20(29-2)22(19)30-3)26-23-24-11-10-21(27-23)25-17-9-8-15-6-4-5-7-16(15)12-17/h4-14H,1-3H3,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human IGF1R				Bioorg Med Chem Lett 21: 2394-9 (2011) Article DOI: 10.1016/j.bmcl.2011.02.075 BindingDB Entry DOI: 10.7270/Q28G8M0D
					More data for this Ligand-Target Pair