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BDBM50340122 CHEMBL1760036::N4-(naphthalen-2-yl)-N2-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine

SMILES: COc1cc(Nc2nccc(Nc3ccc4ccccc4c3)n2)cc(OC)c1OC

InChI Key: InChIKey=OQZLCEIUKFMPCK-UHFFFAOYSA-N

Data: 2 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50340122   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340122
PNG
(CHEMBL1760036 | N4-(naphthalen-2-yl)-N2-(3,4,5-tri...)
Show SMILES COc1cc(Nc2nccc(Nc3ccc4ccccc4c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C23H22N4O3/c1-28-19-13-18(14-20(29-2)22(19)30-3)26-23-24-11-10-21(27-23)25-17-9-8-15-6-4-5-7-16(15)12-17/h4-14H,1-3H3,(H2,24,25,26,27)
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 88n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50340122
PNG
(CHEMBL1760036 | N4-(naphthalen-2-yl)-N2-(3,4,5-tri...)
Show SMILES COc1cc(Nc2nccc(Nc3ccc4ccccc4c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C23H22N4O3/c1-28-19-13-18(14-20(29-2)22(19)30-3)26-23-24-11-10-21(27-23)25-17-9-8-15-6-4-5-7-16(15)12-17/h4-14H,1-3H3,(H2,24,25,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.20n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R


Bioorg Med Chem Lett 21: 2394-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D
More data for this
Ligand-Target Pair