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SMILES: CNC(=O)c1cc2ccc(CCNC(=O)Nc3ccc(C)c(c3)C(F)(F)F)cc2cn1

InChI Key: InChIKey=AIHAKUBEGUDRMK-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50340258   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM50340258
PNG
(CHEMBL1760619 | N-methyl-7-(2-(3-(4-methyl-3-(trif...)
Show SMILES CNC(=O)c1cc2ccc(CCNC(=O)Nc3ccc(C)c(c3)C(F)(F)F)cc2cn1
Show InChI InChI=1S/C22H21F3N4O2/c1-13-3-6-17(11-18(13)22(23,24)25)29-21(31)27-8-7-14-4-5-15-10-19(20(30)26-2)28-12-16(15)9-14/h3-6,9-12H,7-8H2,1-2H3,(H,26,30)(H2,27,29,31)
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Merck Serono

Curated by ChEMBL


Assay Description
Inhibition of human cRAF using [gamma-33P-ATP] as a substrate by scintillation counting

Bioorg Med Chem Lett 21: 2264-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.108
BindingDB Entry DOI: 10.7270/Q2MS3T23
More data for this
Ligand-Target Pair