BDBM50340266 7-(2-(3-(4-chloro-2-methoxy-5-(trifluoromethyl)phenyl)ureido)ethyl)-N-methylisoquinoline-3-carboxamide::CHEMBL1760626

SMILES: CNC(=O)c1cc2ccc(CCNC(=O)Nc3cc(c(Cl)cc3OC)C(F)(F)F)cc2cn1

InChI Key: InChIKey=DMRSVEGZBSPXQN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50340266   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50340266 (7-(2-(3-(4-chloro-2-methoxy-5-(trifluoromethyl)phe...) Show SMILES CNC(=O)c1cc2ccc(CCNC(=O)Nc3cc(c(Cl)cc3OC)C(F)(F)F)cc2cn1 Show InChI InChI=1S/C22H20ClF3N4O3/c1-27-20(31)18-8-13-4-3-12(7-14(13)11-29-18)5-6-28-21(32)30-17-9-15(22(24,25)26)16(23)10-19(17)33-2/h3-4,7-11H,5-6H2,1-2H3,(H,27,31)(H2,28,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Merck Serono Curated by ChEMBL					Assay Description Inhibition of human cRAF using [gamma-33P-ATP] as a substrate by scintillation counting				Bioorg Med Chem Lett 21: 2264-9 (2011) Article DOI: 10.1016/j.bmcl.2011.02.108 BindingDB Entry DOI: 10.7270/Q2MS3T23
					More data for this Ligand-Target Pair