BDBM50340267 7-(2-(3-(4-chloro-2-(2-(dimethylamino)ethoxy)-5-(trifluoromethyl)phenyl)ureido)ethyl)-N-methylisoquinoline-3-carboxamide::CHEMBL1760627
SMILES: CNC(=O)c1cc2ccc(CCNC(=O)Nc3cc(c(Cl)cc3OCCN(C)C)C(F)(F)F)cc2cn1
InChI Key: InChIKey=WKKLKPNLLPOLJN-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50340267 (7-(2-(3-(4-chloro-2-(2-(dimethylamino)ethoxy)-5-(t...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono Curated by ChEMBL | Assay Description Inhibition of human cRAF using [gamma-33P-ATP] as a substrate by scintillation counting | Bioorg Med Chem Lett 21: 2264-9 (2011) Article DOI: 10.1016/j.bmcl.2011.02.108 BindingDB Entry DOI: 10.7270/Q2MS3T23 | |||||||||||
More data for this Ligand-Target Pair |