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SMILES: CNCCOc1cc(Cl)c(cc1NC(=O)NCCc1ccc2nc(NC(C)=O)[nH]c2c1)C(F)(F)F

InChI Key: InChIKey=DJJGOSSNKWFDBX-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50340282   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM50340282
PNG
(CHEMBL1760642 | N-(6-(2-(3-(4-chloro-2-(2-(methyla...)
Show SMILES CNCCOc1cc(Cl)c(cc1NC(=O)NCCc1ccc2nc(NC(C)=O)[nH]c2c1)C(F)(F)F
Show InChI InChI=1S/C22H24ClF3N6O3/c1-12(33)29-20-30-16-4-3-13(9-17(16)31-20)5-6-28-21(34)32-18-10-14(22(24,25)26)15(23)11-19(18)35-8-7-27-2/h3-4,9-11,27H,5-8H2,1-2H3,(H2,28,32,34)(H2,29,30,31,33)
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Merck Serono

Curated by ChEMBL


Assay Description
Inhibition of human cRAF using [gamma-33P-ATP] as a substrate by scintillation counting

Bioorg Med Chem Lett 21: 2264-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.108
BindingDB Entry DOI: 10.7270/Q2MS3T23
More data for this
Ligand-Target Pair